Ruthenium Chemistry 1st Edition by Ajay Kumar Mishra 1351616492 9781351616492

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ISBN-10 :  1351616492 

ISBN-13 :  9781351616492

Author:  Ajay Kumar Mishra 

This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.

Ruthenium Chemistry 1st table of contents:

1. An Introduction to Ruthenium Chemistry
2. Ruthenium in Medicinal Chemistry
2.1 Introduction
2.1.1 General Remarks
2.1.2 Ruthenium Compounds Potentiality as Prospective Drugs
2.2 Ruthenium Antitumoral Compounds
2.2.1 Classic Coordination Compounds
2.2.2 Organometallic Compounds
2.3 Ruthenium Antiparasitic Compounds
2.3.1 Ruthenium Compounds against Trypanosomatid Parasites
2.3.2 Ruthenium Compounds against Malaria Parasites
2.4 Concluding Remarks and Perspectives
3. An Overview of Ruthenium Complexes as a Potential Sensing Agent
3.1 Introduction
3.2 Sensing Property of Ruthenium Complexes
3.3 Ruthenium Complexes as Cation Sensor
3.4 Ruthenium Complexes an Anion Sensor
3.4.1 Anion Sensing through Acidic Hydrogen
3.4.2 Anion Sensing through Lewis Acidic Sites
3.4.3 Anion Sensing through Chemodosimeter Approach
3.5 Ruthenium Complexes as Gas Sensor
3.6 Ruthenium Complexes as Sensing Agent of Neutral Species
3.6.1 Detection of Amino Acids
3.6.2 Detection of DNA Molecule
3.6.3 Detection of Other Biomolecules
3.6.4 Detection of Hazardous Compounds
3.7 pH Sensing
3.8 Temperature Sensing
3.9 Conclusion and Perspective
4. Ruthenium Compounds: A New Approach in Nanochemistry
4.1 Introduction
4.2 Synthesis of Metallic Nanoparticles
4.2.1 Physical Method
4.2.2 Chemical Method
4.2.3 Wet Chemical Synthesis
4.3 Applications of Ru Nanoparticles
4.3.1 Catalytic Application
4.3.1.1 Oxidation
4.3.1.2 Reduction
4.3.1.3 Hydrolysis
4.3.1.4 Hydrogenolysis
4.3.1.5 Olefin metathesis
4.3.1.6 Isotope exchange
4.3.1.7 Miscellaneous catalytic reactions
4.3.2 As Analytical Tool
4.3.3 Biomedical Applications
4.4 Future Prospects
4.5 Conclusions
5. Synthesis and Characterization of Copper-Ruthenium Composites
5.1 Introduction to Microelectronic Packaging Material
5.2 Ruthenium as Emerging Material
5.2.1 Early History of Ruthenium
5.2.2 Ruthenium-Aluminum Alloy
5.3 History of Copper
5.3.1 Ruthenium as Diffusion Barrier in Copper Interconnect
5.3.2 Ruthenium as Alloying Element for Thermal Management Materials
5.3.3 Ruthenium as Oxidation Resistance for Copper
5.4 Processing Techniques of Metal Reinforced with Ruthenium
5.4.1 Powder Metallurgy
5.4.2 Overview of Sintering Process
5.4.3 Spark Plasma Sintering Technique
5.4.4 Sintering of Ruthenium Alloy
5.5 Properties of Ruthenium Alloy
5.5.1 Properties of Copper with Ruthenium Additive
5.5.2 Properties of WC-Co with Ruthenium Additive
5.6 Properties of Ruthenium Oxide
5.6.1 Properties of RuO2 for Supercapacitor Applications
5.7 Conclusion
6. Orbital Tuning of Ruthenium Polyimine Complexes by Ligand Design: From Basic Principles to Applications
6.1 Basic Principles of Orbital Tuning for Ruthenium Polyimine Complexes
6.1.1 Ruthenium Polyimine Complexes
6.1.2 Orbital Tuning of Metal Complexes: A Crash Course on Molecular Orbitals and Ligand Field Theory
6.1.3 Orbitals and Redox and Photophysical Properties of Ruthenium Polyimine Complexes
6.2 Ligand Variation for Orbital Tuning
6.2.1 Cyclometalated Ruthenium Complexes
6.2.2 Azole Ligands
6.2.3 Out-of-Ring Coordination
6.2.4 Active Orbital Tuning: Redox Reactions on Noninnocent Ligands
6.3 Applications of Ruthenium Polyimine Complexes through Orbital Tuning
6.3.1 Dye-Sensitized Solar Cells
6.3.2 Organic Light-Emitting Diodes
7. The Development of Ru(II)–p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents
7.1 Ruthenium Complexes as Anti-Cancer Agents
7.1.1 Ruthenium(II)–Arene Complexes with Pyridine Derivatives as Anti-Cancer Agents
7.1.1.1 Ruthenium(II)–arene complexes with functionalized pyridines
7.1.1.2 Ruthenium(II)–arene complexes with substituted picolinato ligands
7.1.1.3 Ruthenium-p-cymene complexes carrying pyridine or 7-chloroquinolin derivatives
7.1.1.4 Ruthenium(II)–arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3- and 4-acetylpyridine
7.2 Conclusions
8. Approaching Cancer Therapy with Ruthenium Complexes by Their Interaction with DNA
8.1 Introduction
8.2 Brief Introduction to DNA
8.2.1 General Structure
8.2.2 Probable Interaction Sites
8.2.2.1 Irreversible binding to DNA
8.2.2.2 Reversible binding to DNA
8.2.3 Mode of Binding and Their Detection Using Spectroscopic and Biochemical Techniques
8.2.3.1 UV-visible absorption spectroscopy
8.2.3.2 Fluorescence spectroscopy
8.2.3.3 Viscosity measurements
8.2.3.4 Circular dichroism
8.2.3.5 Nuclear magnetic resonance spectroscopy
8.2.3.6 X-Ray crystallography
8.2.3.7 Gel electrophoresis
8.3 Cytotoxicity of Ruthenium Complexes
8.3.1 Dimethyl Sulfoxide Complexes
8.3.2 Heterocyclic Complexes
8.3.3 Polypyridyl Compounds
8.3.4 Ruthenium(II) Arene Complexes
8.4 Conclusions
9. Ruthenium Aryl Sulfides Complexes
9.1 Introduction
9.2 Aryl Thiols
9.3 Ortho-Substituted Aryl Thiols
9.3.1 Thiosalicylic Acid
9.3.2 Hydroxythiophenol
9.3.3 Aminothiophenol
9.4 Diaryl Sulfides
9.4.1 Diaryl Monosulfide Complexes
9.4.2 Diaryl Disulfide Complexes
9.5 Conclusion
10. Tuning of Ruthenium-DMSO Complexes for Search of New Anticancer Agents
10.1 Introduction
10.2 Historical Background
10.3 Primary Targets for the Development of Metal-Based Therapeutic Agents
10.4 Types of Ruthenium-DMSO Complexes
10.4.1 Ruthenium-DMSO Complexes Containing N-Coordinated Ligands
10.4.2 Ruthenium-DMSO Complexes Containing O-Coordinated Ligands
10.4.3 Ruthenium-DMSO Complexes Containing N,O-Coordinated Ligands
10.5 Mechanism of Action of Ru-DMSO Complexes
10.6 Conclusion

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Tags: Ruthenium, Chemistry, Ajay Kumar Mishra