Assessing Nanoparticle Risks to Human Health 2nd Edition by Gurumurthy Ramachandran 0323353231 9780323353236

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ISBN-10 :  0323353231 

ISBN-13 :  9780323353236

Author: Gurumurthy Ramachandran 

Assessing Nanoparticle Risks to Human Health provides a systematic overview of nanoparticle risks and considers the limitations of this paradigm in a context where extreme uncertainties prevail. As well as exploring conventional risk assessment methodology, the contributing authors investigate several alternate approaches. The adequacy of current frameworks for risk management and regulatory oversights, including corporate approaches in the US and EU, are explored, and suggestions are made as to how these frameworks can be modified to make them more efficient and effective. Presenting a coherent framework for analysis of the available information, this book presents the latest scientific understanding of the toxicity and health effects of nanoparticles, the technical issues relating to exposure assessment and management, and the ways in which the current risk paradigm can be used/modified to deal with the challenges of nanoparticle risks.

Assessing Nanoparticle Risks to Human Health 2nd Table of contents:

Chapter 1. The Challenge of Nanomaterial Risk Assessment
Abstract
1.1 Introduction
1.2 The Nature of the Nanomaterial Challenge
1.3 The Problem with Definitions
1.4 Principles-Based Problem Formulation for Engineered Nanomaterials
1.5 Applying the Three Principles to Engineered Nanomaterials
1.6 Responsible Research and Innovation
1.7 Looking Forward
References
Chapter 2. Assessing and Managing Exposures to Nanomaterials in the Workplace
Abstract
2.1 A General Strategy to Assess Workplace Exposures
2.2 Uncertainties Introduced by Nanotechnology
2.3 Exposure Routes
2.4 Occupational Exposure Limits
2.5 Instruments Available to Assess Exposures
2.6 Specific “Best Practices” for Exposure Assessment Strategy in Nanotechnology
References
Chapter 3. Hazard and Risk Assessment of Workplace Exposure to Engineered Nanoparticles: Methods, Issues, and Carbon Nanotube Case Study
Abstract
3.1 Introduction
3.2 Case Study Example: Carbon Nanotubes
3.3 Discussion
References
Appendix: Pulmonary Ventilation Rate Calculations
Chapter 4. Lung Bioassay Methodologies for Assessing Hazards After Exposures to Nanoscale or Fine Particulates
Abstract
4.1 Introduction and General Background
4.2 Subchronic Inhalation Study in Rats with Carbon Nanofibers—OECD Test Guideline 413
4.3 Conclusions
References
Chapter 5. Using Expert Judgment for Risk Assessment
Abstract
5.1 Introduction: Uncertainties in Risk Assessment
5.2 Limitations of Existing Methodologies for Risk Assessment and Precedents for Using Expert Judgment
5.3 Eliciting Expert Judgment—Selection of Experts, Elicitation Protocols, and Best Practices
5.4 Arriving at Consensus Risk Estimates
5.5 The Use of Expert Judgment for Nanoparticle Risks
5.6 Expert Judgment in the Development of a Nanomaterial Risk Screening Tool
5.7 Conclusions
References
Chapter 6. Risk Assessment Using Control Banding
Abstract
6.1 Introduction
6.2 Challenges Related to the Traditional Industrial Hygiene Approach
6.3 Control Banding and Risk Prioritization Tools for Nanomaterials
6.4 ISO Standard on Use of the Control Banding Approach
6.5 CB Nanotool
6.6 Evaluation of the CB Nanotool
6.7 Quantitative Validation of the CB Nanotool
6.8 Considerations for the Nanotechnology Industry
6.9 Conclusion
Acknowledgments
References
Chapter 7. Controlling Nanoparticle Exposures
Abstract
7.1 Introduction
7.2 The Hierarchy of Control
7.3 Criteria for Prioritizing Control Options
7.4 Form of Nanomaterials
7.5 Local Exhaust Ventilation
7.6 Air Pollution Control Devices
7.7 Work Practices
7.8 Personal Protective Equipment
7.9 Summary and Recommendations
References
Chapter 8. Addressing the Risks of Nanomaterials under United States and European Union Regulatory Frameworks for Chemicals,
Abstract
8.1 Introduction
8.2 U.S. Chemicals Regulation
8.3 European Union Chemicals Regulation
8.4 Comparative Analysis
8.5 Conclusion

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Tags: Assessing, Nanoparticle Risks, Human Health, Gurumurthy Ramachandran