Antibody Therapy 1st edition by Paul Imbach 3319680374 9783319680378

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ISBN-10 :  3319680374 

ISBN-13 :  9783319680378

Author:  Paul Imbach 

This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.

Antibody Therapy 1st Table of contents:

1. The Clinical Translation of Intravenous Immunoglobulin from Substitution to Immunomodulation
Part I. Update of Substitutive and Immunomodulatory Antibodies/Drugs Indications
2. From Immune Substitution to Immuno-modulation
3. Manual of Primary and Secondary Immunodeficiencies
4. Manual of Intravenous and Subcutaneous IgG Indications in Autoimmune Diseases
5. Anti-D: A Type of IVIg
6. Mechanisms of Action and Immunomodulation by IVIg
7. Immunomodulatory Drugs and Monoclonal Antibodies
8. Use of Intravenous Immunoglobulin in Neurology
9. Use of Intravenous Immunoglobulin in Dermatology
Part II. Basics of IgG Concentrates
10. Historical Aspects of Polyclonal IgG Preparations
11. Basics of Immunoglobulins as Effector Molecules and Drugs
12. Essentials of the Production of Safe and Efficacious State-of-the-Art Polyclonal IgG Concentrates
13. Current IgG Products and Future Perspectives
Part III. Immune Thrombocytopenia: The First Immunomodulatory IgG Treatment
14. Updates in Immune Thrombocytopenia: Terminology, Immunomodulation and Platelet Stimulation, and Clinical Guidelines and Management
15. Health-Related Quality of Life in Patients with Immune Thrombocytopenia
16. ITP in Childhood: Predictors of Disease Duration
17. Immune Functions of Platelets
18. Thrombopoietin Receptor Agonists: Characteristics, Adverse Effects, and Indications
19. Registries in Immune Thrombocytopenia: The History of the Intercontinental Cooperative ITP Study Group
Part IV. Translation from Polyclonal to Monoclonal Antibody Treatment
20. Therapeutic Monoclonal Antibodies as Immunomodulators and Anti-Cancer Agents: Development, Evidence of Efficacy, Mechanisms of Actions, Adverse Effects
21. Monoclonal Anti-CD20 (B-Cell) Antibody and Autoimmune Diseases

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