Congenital Hyperinsulinism A Practical Guide to Diagnosis and Management 1st Edition by Diva D De León Crutchlow, Charles A Stanley ISBN 9783030029609 3030029603

Congenital Hyperinsulinism A Practical Guide to Diagnosis and Management 1st Edition by Diva D. De León-Crutchlow, Charles A. Stanley- Ebook PDF Instant Download/Delivery: 9783030029609, 3030029603

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Product details:

ISBN 10: 3030029603

ISBN 13: 9783030029609

Author: Diva D. De León-Crutchlow, Charles A. Stanley

 This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, andlong-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter.
Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.

Table of contents: 

1. Approach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia

2. Diazoxide-Responsive Forms of Congenital Hyperinsulinism

3. Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism

4. Syndromic Causes of Congenital Hyperinsulinism

5. Molecular Diagnosis of Congenital Hyperinsulinism

6. Medical Management of Hyperinsulinism

7. 18F-DOPA PET

8. Histopathology of the Pancreas in Congenital Hyperinsulinism

9. Surgery for Congenital Hyperinsulinism

10. Perioperative Management of Hyperinsulinism

11. Management of the Child with Persistent Hypoglycemia After Surgery

12. Management of Diabetes and Pancreatic Insufficiency After Pancreatectomy

13. Feeding Problems in Congenital Hyperinsulinism

14. Neurodevelopmental Outcomes

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Tags: Diva D De León Crutchlow, Charles A Stanley, Congenital, Hyperinsulinism, Practical Guide, Diagnosis, Management