Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues 1st Edition by Irving Shapiro, William Landis ISBN 3031343026 978-3031343025

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ISBN 10: 3031343026
ISBN 13: 978-3031343025
Author: Irving Shapiro, William Landis 

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.

The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues 1st Table of contents:

1. In the Beginning

2. The Enigma of Edith: Free Energy, Nucleation, and the Formation of Mineral

3. Form and Function of Tissues which Undergo Mineralization

4. Genes and Gene Networks Regulating Mineralization

5. Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues

6. Calcium and Phosphate Ion Efflux from Cells: The Roles of Matrix Vesicles, Extracellular Vesicles, and Other Membrane-invested Transporters in Vertebrate Hard Tissue Mineralization

7. Collagen-based Mineralization of Bones, Teeth, and Other Vertebrate Skeletal Tissues

8. The Role of Non-collagenous Proteins and Other Matrix Molecules in Vertebrate Mineralization

9. Local and Systemic Regulation of Mineralization: Role of Coupling Factors, Pyrophosphate, Polyphosphates, Vitamin D, Fetuin, Matrix Gla Protein, and Osteopontin

10. Aberrant Mineral Deposition in Soft and Hard Tissues

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Tags: Irving Shapiro, William Landis, Vertebrate Skeletal, Dental Tissues