Nanoceramics in Clinical Use From Materials to Applications 2nd Edition by María Vallet-Regi, Daniel Arcos Navarrete – Ebook PDF Instant Download/DeliveryISBN: 1782627050, 9781782627050
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ISBN-10 : 1782627050
ISBN-13 : 9781782627050
Author: María Vallet-Regi, Daniel Arcos Navarrete
The field of nanoceramics for biomedical applications has experienced important advances in the last five years. These advances are mainly focused in the field of new nanostructured bioceramics able to mimic almost the same biomineralization processes. In addition, there has also been significant advances in nanoceramics as vehicles for targeted drug delivery and gene therapy. Building on the success of Biomimetic Nanoceramics in Clinical Use, this second edition has been revised and updated to reflect the recent developments in the field. Nanoceramics in Clinical Use includes additional material on bone mineralization processes, new synthesis strategies and applications of nanostructured bioceramics to manufacture 3D macroporous scaffolds and as nanovehicles for targeted drug delivery and gene therapies, to provide the reader with a complete overview of the topic, from fundamental principles to the latest advances. Written by World leading experts in bioceramics, this title will appeal to a broad audience, from academic researchers to those working within the commercial industry. Materials and chemical engineers, chemists, biologists, physicists and those working in medicine, im particular with medical implants, will appreciate the comprehensive coverage of this fast-developing area.
Nanoceramics in Clinical Use From Materials to Applications 2nd table of contents:
Chapter 1 Biological Apatites in Bone and Teeth
1.1 Hard-Tissue Biomineralization: How Nature Works
1.1.1 Bone Formation
1.1.2 A Discussion on Biomineralization
1.1.3 Biomineralization Processes
1.1.4 Biominerals
1.1.5 Inorganic Components: Composition and Most-Frequent Structures
1.1.6 Organic Components: Vesicles and Polymer Matrices
1.2 Alternative Ways to Obtain Nanosized Calcium-Deficient Carbonate-Hydroxy-Apatites
1.2.1 The Synthetic Route
1.2.2 The Biomimetic Process
References
Chapter 2 Synthetic Nanoapatites
2.1 Introduction
2.1.1 General Remarks on the Reactivity of Solids
2.1.2 Objectives and Preparation Strategies
2.2 Synthesis Methods
2.2.1 Synthesis of Apatites by the Ceramic Method
2.2.2 Synthesis of Apatites by Wet-Route Methods
2.2.3 Synthesis of Apatites by Aerosol Processes
2.2.4 Other Methods Based on Precipitation from Aqueous Solutions
2.2.5 Apatites in the Absence of Gravity
2.2.6 Carbonate Apatites
2.2.7 Silica as a Component in Apatite Precursor Ceramic Materials
2.2.8 Apatite Coatings
2.2.9 Precursors to Obtain Apatites
2.2.10 Additional Synthesis Methods
2.2.11 Sintered Apatites
2.2.12 Bioinspired Synthesis of Nanoapatites
References
Chapter 3 Bioceramics Forming Nanoapatites
3.1 Introduction
3.1.1 Biomimetic Nanoapatites and Bioactive Ceramics
3.1.2 Biomimetic Nanoapatites on Nonceramic Biomaterials; Two examples: Polyactive® and Titanium Alloys
3.1.3 Significance of Biomimetic Nanoapatite Growth on Bioceramic Implants
3.2 Simulated Physiological Solutions for Biomimetic Procedures
3.3 Biomimetic Crystallization Methods
3.4 Calcium Phosphate Bioceramics
3.4.1 Bone Tissue Response to Calcium Phosphate Bioceramics
3.4.2 Reactivity of Calcium Phosphate Bioceramics with the Biological Environment
3.4.3 Physical-Chemical Events in CaP Bioceramics During the Biomimetic Process
3.5 Biomimetic Nanoceramics on Hydroxyapatite and Advanced Apatite-Derived Bioceramics
3.5.1 Hydroxyapatite, Oxyhydroxyapatite and Ca-Deficient Hydroxyapatite
3.5.2 Silicon-Substituted Apatites
3.6 Biphasic Calcium Phosphates (BCPs)
3.6.1 An Introduction to BCPs
3.6.2 Biomimetic Nanoceramics on BCP Biomaterials
3.7 Biomimetic Nanoceramics on Bioactive Glasses
3.7.1 An Introduction to Bioactive Glasses
3.7.2 Composition and Structure of Melt-Derived Bioactive Glasses
3.7.3 Sol-Gel Bioactive Glasses
3.7.4 The Bioactive Process in SiO2-Based Glasses
3.7.5 Biomimetic Nanoapatite Formation on SiO2-Based Bioactive Glasses
3.7.6 Role of P2O5 In Vitro Bioactivity of Sol-Gel Glasses
3.7.7 Biomimetism Evaluation on Silica-Based Bioactive Glasses
3.8 Mesoporous Bioactive Glasses (MBGs)
3.8.1 Structures and Compositions
3.8.2 The Bioactive Behaviour of MBGs
3.9 Biomimetism in Organic-Inorganic Hybrid Materials
3.9.1 An Introduction to Organic-Inorganic Hybrid Materials
3.9.2 Synthesis of Biomimetic Nanoapatites on Class I Hybrid Materials
3.9.3 Synthesis of Biomimetic Nanoapatites on Class II Hybrid Materials
3.9.4 Bioactive Star-Gels
References
Chapter 4 Medical Applications of Bioactive Nanoceramics
4.1 Introduction
4.2 Nanoceramics for Bone-Tissue Regeneration
4.2.1 Bone Cell Adhesion on Nanoceramics: The Role of the Proteins on the Specific Cell-Material Attachment
4.2.2 Bioinspired Nanoapatites: Supramolecular Chemistry as a Tool for Better Bioceramics
4.3 Nanocomposites for Bone-Grafting Applications
4.3.1 Nano-HA-Based Composites
4.3.2 Mechanical Properties of HA-Derived Nanocomposites
4.3.3 Nanoceramic Filler and Polymer Matrix Anchorage
4.3.4 Significance of the Nanoparticle Dispersion Homogeneity
4.3.5 Biocompatibility Behaviour of HA-Derived Nanocomposites
4.3.6 Nanocomposite-Based Fibres
4.3.7 Nanocomposite-Based Microspheres
4.3.8 Nanocomposite Scaffolds for Bone-Tissue Engineering
4.4 Nanostructured Biomimetic Coatings
4.4.1 Sol-Gel-Based Nano-HA Coatings
4.4.2 Nano-HA Coatings Prepared by Biomimetic Deposition
4.5 Nanoapatites for Diagnosis and Drug/Gene-Delivery Systems
4.5.1 Biomimetic Nanoapatites as Biological Probes
4.5.2 Biomimetic Nanoapatites for Drug and Gene Delivery
4.6 Bioactive Glasses for Drug Delivery
4.7 Sol-Gel Silica Glasses as Scaffolds for Bone Tissue Engineering
4.8 Mesoporous Bioactive Glasses for Drug Delivery
4.8.1 Bioactive Mesoporous Microspheres
4.9 MBG Scaffolds for Regenerative Bone Therapies
References
Chapter 5 Mesoporous Materials: From Macro to Nano
5.1 What is a Mesoporous Material?
5.2 Discovery
5.3 Chemistry
5.3.1 From Bulk to Mesoporous Nanoparticles
5.3.2 Expansion in Compositions: Not Only Silica
5.4 Structural Features
5.5 Potential Modifications to the Mesostructure
5.6 Significance in the Clinical Field
5.7 From Bulk to Nano: Potential Use in Nanomedicine
References
Chapter 6 Mesoporous Nanoceramics for Drug Delivery
6.1 What is Nanomedicine?
6.1.1 The Link Between Biotechnology and Medicine
6.2 What is a nanocarrier?
6.3 Ceramic Nanoparticles in Medicine
6.3.1 Mesoporous Silica Nanoparticles
6.3.2 Calcium Phosphate Nanoparticles
6.3.3 Carbon Allotropes
6.3.4 Iron Oxide Nanoparticles
6.4 Administration
6.5 Design of Nanocarriers
6.5.1 Biodistribution and Excretion/Clearance Pathways
6.6 Passive Targeting
6.6.1 Enhanced Permeation and Retention Effect
6.6.2 Tumor Microenvironment
6.7 Active Targeting
6.7.1 Angiogenesis-Associated Active Targeting
6.8 Preparation of Nanocarriers
6.8.1 Synthesis
6.8.2 Loading
6.8.3 Stimulus-Response Systems
6.8.4 Different Kinds of Stimuli
6.9 Other Applications of Nanoparticles in Nanomedicine: Imaging and Theranostic Applications
6.9.1 Mesoporous Silica Nanoparticles
6.9.2 Carbon Allotropes
6.9.3 Iron Oxide Nanoparticles
6.10 Some Thoughts on Toxicity
References
Chapter 7 Magnetic Nanoceramics for Biomedical Applications
7.1 Introduction
7.2 Structure and Magnetic Properties of Iron Oxide Nanoparticles
7.2.1 Magnetic Properties of Iron Oxide Nanoparticle Colloids
7.3 Synthesis of Magnetic Iron Oxide Nanoparticles
7.3.1 Co-Precipitation Synthesis
7.3.2 Microemulsion Synthesis
7.3.3 Solidification of Solid Solutions
7.3.4 Aerosol-Assisted Methods
7.4 Surface Functionalization of SPIONs
7.4.1 Stabilization of Iron Oxide Nanoparticles
7.4.2 Active Targeting Agents
7.5 Biomedical Applications of Magnetic Nanoparticles
7.5.1 Magnetic Nanoparticles in MRI
7.5.2 Hyperthermia Treatment of Cancer
7.5.3 Magnetofection
7.5.4 Drug Delivery
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Tags: Nanoceramics, Clinical Use, Materials, Applications, María Vallet Regi, Daniel Arcos Navarrete