Phytochemicals as Lead Compounds for New Drug Discovery: Prospects for Sustainable Agriculture 1st Edition Chukwuebuka 0128178914 9780128178911 

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Product details:

• ISBN 10: 0128178914 
• ISBN 13: 9780128178911 
• Author: Chukwuebuka Egbuna

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.

Table of contents:

Part I. Plants as natural sources of drugs
Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs

Chapter 2. Factors affecting the choice for plant-based products in drug discoveries

Chapter 3. Advances in computer-aided drug discovery

Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward

Part II. Biofunctional leads for drug development
Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases

Chapter 6. Natural bioactive lead compounds effective against haematological malignancies

Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer

Chapter 8. Antidiabetic lead compounds and targets for drug development

Chapter 9. Antiobesity functional leads and targets for drug development

Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases

Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks

Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases

Chapter 13. Bioactive lead compounds effective against skin diseases

Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment

Chapter 15. Antiviral phytocompounds for drug development: a data mining studies

Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus

Chapter 17. Antimicrobial lead compounds from marine plants

Chapter 18. Antibacterial lead compounds and their targets for drug development

Chapter 19. Awareness and current therapeutic strategies of malaria

Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs

Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs

Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility

Chapter 23. Prenylated flavonoids as a promising drug discovery candida

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