Signaling mechanisms regulating T cell diversity and function 1st Edition by Dietmar Kappes, Jonathan Soboloff 1315354422 9781315354422

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Product details:

ISBN-10 :  1315354422 

ISBN-13 :  9781315354422

Author:   Dietmar Kappes, Jonathan Soboloff 

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Signaling mechanisms regulating T cell diversity and function 1st Table of contents:

Chapter 1 Consequences of Blocking the Choreography of Double Negative Thymocyte Maturation
Chapter 2 In Situ Analysis of T Cell Receptor Signals during Positive Selection
Chapter 3 Regulation of Negative Selection in the Thymus by Cytokines: Novel Role of IL-23 to Regulate RORγt
Chapter 4 Modulating Thymic Negative Selection with Bioengineered Thymus Organoids
Chapter 5 ThPOK, a Key Regulator of T Cell Development and Function
Chapter 6 TCR Signaling Circuits in αβ/γδ T Lineage Choice
Chapter 7 Phenotypic and Functional Characterization of Regulatory T Cell Populations
Chapter 8 Natural Killer T (NKT) Cells in Mice and Men
Chapter 9 Transmission of T Cell Receptor-Mediated Signaling via the GRB2 Family of Adaptor Proteins
Chapter 10 Defining the Roles of Ca2+ Signals during T Cell Activation
Chapter 11 Histone Methyltransferases and T Cell Heterogeneity
Chapter 12 Models of Regulatory T Cell Alterations and Systemic Autoimmunity

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Tags: Signaling mechanisms, function, Dietmar Kappes, Jonathan Soboloff