The Heparins Basic and Clinical Aspects 1st Edition by David Green 0128187816 9780128187814

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ISBN-10 :  0128187816 

ISBN-13 :  9780128187814

Author:   David Green 

The Heparins: Properties and Clinical Applications brings the latest information on heparin, one of the world’s most widely used drugs. The book describes the fascinating history of the discovery of this biological agent, how it was isolated and characterized, and its use for the treatment of thrombotic disorders. The structures of various heparins are illustrated, with their function as anticoagulants delineated. This comprehensive resource arms researchers and clinicians with a concise and practical source that will assist in biomedical research, medical practice, and in improving patient outcomes.

The Heparins: Basic and Clinical Aspects 1st Table of contents:

Part I: Historical Development and Properties
Chapter 1. Anticoagulant heparins
Abstract
Discovery
Structure
Pharmacokinetics
Pharmacodynamics
Clinical development
Routes of administration
Monitoring heparin
Heparin analogs
References
Chapter 2. Non-anticoagulant heparins
Abstract
Release of lipases
Defense of the endothelium
Effects on cell proliferation
Inhibition of heparan sulfate cleavage by heparanase
Retardation of inflammation
Effects on bone
Decrease of blood viscosity
Suppression of aldosterone
Non-thrombotic disorders potentially amenable to treatment with heparins
Non-anticoagulant heparins for clinical applications
References
Part II: Anticoagulant Heparins: Clinical Applications
Chapter 3. Prevention of thrombosis
Abstract
Hip arthroplasty and hip fracture
Knee arthroplasty and knee arthroscopy
Abdominal surgery
Cardiac surgery
Neurosurgery
Acute spinal cord injury
Medical inpatients
Cancer inpatients and outpatients
Thromboprophylaxis in stroke patients
Arterial occlusion
Catheter patency
Dose modification for obesity or renal impairment
Pregnancy
Pediatrics
References
Chapter 4. Treatment of thrombosis
Abstract
Venous thrombosis
Arterial disease
Summary
References
Part III: Adverse Effects
Chapter 5. Bleeding, Heparin-induced thrombocytopenia, and Other adverse reactions
Abstract
Bleeding
Heparin-induced thrombocytopenia
Skin reactions
Osteoporosis
Hyperkalemia and elevation of transaminases

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Tags: The Heparins, Basic, Clinical Aspects, David Green