Therapeutic antibody engineering current and future advances driving the strongest growth area in the pharmaceutical industry 1st Edition Strohl 9781908818096

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Product details:

• ISBN 13: 9781908818096
• Author: W R Strohl

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics.

Table of contents:

Chapter 1: Introduction to biologics and monoclonal antibodies

Chapter 2: Value proposition for therapeutic monoclonal antibodies and Fc fusion proteins

Chapter 3: Antibody structure–function relationships

Chapter 4: Fundamental technologies for antibody engineering

Chapter 5: Sources of antibody variable chains

Chapter 6: Variable chain engineering – humanization and optimization approaches

Chapter 7: Antibody interactions with the immune system

Chapter 8: Monoclonal antibody targets and mechanisms of action

Chapter 9: Therapeutic antibody classes

Chapter 10: Antibody Fc engineering for optimal antibody performance

Chapter 11: IgG glycans and glyco-engineering

Chapter 12: Antibody fragments as therapeutics

Chapter 13: Multiple antibody and multi-specificity approaches

Chapter 14: FcFPs and similar constructs using Fc

Chapter 15: Antibody-drug conjugates

Chapter 16: Development issues: antibody stability, developability, immunogenicity, and comparability

Chapter 17: Interactions of human IgGs with non-human systems

Chapter 18: Cell line development

Chapter 19: Issues facing therapeutic monoclonal antibodiesfor the future

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