A Handbook for DNA Encoded Chemistry Theory and Applications for Exploring Chemical Space and Drug Discovery 1st Edition by Robert A Goodnow Jr ISBN 9781118487686 1118487680

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Product details:

ISBN 10:  1118487680

ISBN 13: 9781118487686

Author: Robert A. Goodnow Jr.

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology.

Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

• Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
• Helps chemists generate and screen novel chemical libraries of large size and quality
• Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
• Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery
• Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

Table of contents: 

Chapter 1: Just Enough Knowledge…
Chapter 2: A Brief History of the Development of Combinatorial Chemistry and the Emerging Need for DNA-Encoded Chemistry
Chapter 3: A Brief History of DNA-Encoded Chemistry
Chapter 4: DNA-Compatible Chemistry
Chapter 5: Foundations of a DNA-Encoded Library (DEL)
Chapter 6: Exercises in the Synthesis of DNA-Encoded Libraries
Chapter 7: The DNA Tag: A Chemical Gene Designed for DNA-Encoded Libraries
Chapter 8: Analytical Challenges for DNA-Encoded Library Systems
Chapter 9: Informatics: Functionality and Architecture for DNA-Encoded Library Production and Screening
Chapter 10: Theoretical Considerations of the Application of DNA-Encoded Libraries to Drug Discovery
Chapter 11: Begin with the End in Mind: The Hit-to-Lead Process
Chapter 12: Enumeration and Visualization of Large Combinatorial Chemical Libraries
Chapter 13: Screening Large Compound Collections
Chapter 14: Reported Applications of DNA-Encoded Library Chemistry
Chapter 15: Dual-Pharmacophore DNA-Encoded Chemical Libraries
Chapter 16: Hit Identification and Hit Follow-Up
Chapter 17: Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding
Chapter 18: The Changing Feasibility and Economics of Chemical Diversity Exploration with DNA-Encoded Combinatorial Approaches
Chapter 19: Keeping the Promise? An Outlook on DNA Chemical Library Technology

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Tags: Robert A Goodnow Jr , Handbook, DNA Encoded Chemistry, Theory, Applications, Exploring Chemical Space, Drug Discovery