Scaffold Hopping in Medicinal Chemistry 1st Edition by Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ISBN 9783527333646 3527333649

Scaffold Hopping in Medicinal Chemistry 1st Edition by Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers  – Ebook PDF Instant Download/Delivery: 9783527333646, 3527333649
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Product details: 

ISBN 10:  3527333649

ISBN 13: 9783527333646

Author: Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader’s own projects.

The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry.

While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

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Table of contents: 

Part One: Scaffolds: Identification, Representation Diversity, and Navigation

Part Two: Scaffold-Hopping Methods

Part Three: Case Studies

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Tags: Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Scaffold Hopping, Medicinal Chemistry