Biological fluid surface interactions in detection and medical devices 1st Edition by Michael Thompson, Christophe Blaszykowski, Sonia Sheikh, Cesar Rodriguez Emmenegger, Andres de los Santos Pereira 1782628941 9781782628941

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Product details:

ISBN-10 :  1782628941

ISBN-13 :  9781782628941

Author:  Michael Thompson, Christophe Blaszykowski, Sonia Sheikh, Cesar Rodriguez-Emmenegger, Andres de los Santos Pereira  

With development of implants and in vivo detection devices comes the complication of the interaction between the materials used in the devices and biological fluids. This book examines these interactions causing fouling in biosensors and the serious issue of thrombus formation. The chemistry of surface-protein and surface-cell interactions is considered, the coatings and strategies re the avoidance of fouling are compared and the expert contributors provide a comprehensive look at the physical chemistry of the implant surface and the fouling problem. Finishing with a discussion of the future for surface modified biosensors in point-of-care devices and microfluidic technologies, this book provides an important addition to the literature suitable for professional researchers in academia and industry and postgraduate students.

Biological fluid surface interactions in detection and medical devices 1st Table of contents:

Chapter 1 Relevant Aspects of Surface Physical Chemistry
1.1 Introduction
1.1.1 Materials and Biological Systems – The Biomaterials Interface
1.1.2 The Problem of Fouling
1.2 Interfaces and Their Properties
1.2.1 Definition and Thermodynamic Aspects
1.2.2 Surface Tension and Surface Free Energy
1.2.3 Wetting: Contact Angle and Capillarity
1.2.4 Surface Chemistry and Functionality
1.2.5 Mesoscopic Forces Acting on Surfaces
1.2.6 Surface Morphology
1.3 Surface Characterization Methods
1.3.1 Surface Chemical Characterization Techniques
1.3.2 Contact Angle Techniques
1.3.3 Surface Structure and Morphology
1.3.4 Surface–Biomolecule Interactions
References
Chapter 2 Protein Adsorption on Surfaces: Understanding the Complex Nature of a Common Phenomenon
2.1 Protein Adsorption on Surfaces: a Brief Overview of a Critical Issue
2.2 Structural Complexity and Diversity of Proteins
2.3 Protein–Surface Interaction
2.3.1 A Glimpse into Protein Adsorption
2.3.2 Mechanism of Protein Adsorption: a Molecular Perspective
2.3.3 Kinetics, Thermodynamics, and Dehydration
2.3.4 General Governing Principles: a Tale of Caution
2.3.5 Protein Adsorption Models
2.4 The Case of Blood and its Plasma/Serum Derivatives
2.4.1 Blood: the Proteinaceous Biofluid of Life
2.4.2 Deleterious Consequences of Blood-artificial Surface Interaction in the Biomedical and Bioanalytical Fields: an Overview
2.5 Conclusion
References
Chapter 3 Interaction of Cells and Tissue with Substrate Surfaces
3.1 Cells and Substrate Physicochemical Properties
3.2 The Eukaryotic Cell and Extracellular Matrix
3.3 Cells
3.3.1 Cells in Blood
3.3.2 The Neuron
3.3.3 Some Cells Used in Model Substrate Studies
3.4 Interaction of Cells with Substrates: Adhesion, Growth, Guidance, and Proliferation
3.4.1 Bare and Treated Polymer and Metal Substrates
3.4.2 Polypeptide Coatings
3.4.3 Extracellular Matrix Proteins and Derived Peptides
3.4.4 Substrate Morphology
3.4.5 Substrate Rigidity and Elasticity
3.5 Nanoparticles, Theranostics, and Nanotoxicology
References
Chapter 4 Biological Consequences of the Blood–Surface Interaction
4.1 Biological Response to Biomaterials – General Concepts
4.1.1 Protein Fouling: the Initial Step
4.1.2 Blood Coagulation and Blood–Material Interactions
4.1.3 Inflammatory Reactions and the Foreign Body Response
4.1.4 Complement System
4.1.5 Infection and Biofilm Formation
4.1.6 Effect of Flow Regime in Blood–Surface Interactions
4.1.7 Tumorigenesis
4.2 Blood-Contacting Devices
4.2.1 Vascular Stents
4.2.2 Vascular Grafts
4.2.3 Prosthetic Heart Valves
4.2.4 Extracorporeal Blood Circulation
4.2.5 Fouling and Label-free Biosensing
References
Chapter 5 Antifouling Surface Chemistries to Minimize Signal Interference from Biological Matrices in Biosensor Technology
5.1 The Issue of Signal Interference from the Biological Matrix in Biosensor Technology
5.2 State-of-the-art Antifouling Surface Chemistries
5.2.1 Against Blood Plasma/Serum
5.2.2 Against Other Human or Animal Biofluids
5.2.3 At-a-glance Summary
5.3 Implementation in Biosensor Technology
5.3.1 Biofunctionalization of Peptide SAMs
5.3.2 Biofunctionalization of Polyelectrolyte Films
5.3.3 Biofunctionalization of PLL-g-PEG Films
5.3.4 Biofunctionalization of Ionic Liquid SAMs
5.3.5 Biofunctionalization of Polysaccharidic Coatings
5.3.6 Biofunctionalization of Polymer Brushes
5.4 Conclusion and Outlook
References and Notes
Chapter 6 Prevention of Deleterious Biofluid–Surface Interactions in Detection and Medical Devices: A Look into the Future
6.1 On the Mechanism of Surface Resistance to Protein Adsorption: Schools of Thought and Rationalization
6.1.1 Physical View
6.1.2 Chemical View: the Pivotal Cloaking Role of Water
6.1.3 Surface Hydration and Antifouling: A Rationalization of their Connection through both Empirical and Computational Evidence
6.2 Ultrathin Surface Chemistry for Biocompatibility Enhancement
6.3 Rational Design of Biocompatible Materials
6.4 The Future in Practice
6.4.1 Antifouling Surface Chemistry: Coating vs. Biosample Nature/Source
6.4.2 Implants: Tissue Healing and Bacterial Infection
6.4.3 Bioanalysis and the Universalization of Biosensor Technology

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