Metal Chelation in Medicine 1st Edition Robert Crichton 1782623892 9781782623892

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Product details:

• ISBN 10: 1782623892
• ISBN 13: 9781782623892
• Author: Robert Crichton

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning.
Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Table of contents:

Chapter 1 – Metal Toxicity – An Introduction

Chapter 2 – Basic Principles of Metal Chelation and Chelator Design

Chapter 3 – Chelation Therapy For Heavy Metals

Chapter 4 – Treatment of Systemic Iron Overload

Chapter 5 – Treatment of Neurodegenerative Diseases by Chelators

Chapter 6 – Chelation of Actinides

Chapter 7 – Evaluation of Iron Overload by Non-Invasive Measurement Techniques

Chapter 8 – Chelators for Diagnostic Molecular Imaging with Radioisotopes of Copper, Gallium and Zir

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