A Primate Model for the Study of Colitis and Colonic Carcinoma 1st edition by Neal Clapp- Ebook PDF Instant Download/Delivery: 9781315890319,1315890313
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ISBN 10: 1315890313
ISBN 13: 9781315890319
Author: Neal Clapp
A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
A Primate Model for the Study of Colitis and Colonic Carcinoma 1st Table of contents:
A. Historical Background of Callitrichids
Chapter 1 The Colombian Cotton-Top Tamarin in the Wild
Chapter 2 Breeding the Cotton-Top Tamarin (Saguinus oedipus) in Captivity
Chapter 3 Callitrichid Nutrition
B. Inflammatory Bowel Disease in Callitrichids
Chapter 4 Natural History, Time Course, and Pathogenesis of Idipathic Colitis in Cotton-Top Tamarins (Saguinus oedipus)
Chapter 5 The Prevalence of Idiopathic Colitis in the New England Regional Primate Research Center Cotton-Top Tamarin (Saguinus oedipus) Colony
Chapter 6 An Antigenic Profile in Cotton-Top Tamarins—Saguinus oedipus—A Model for Human Inflammatory Bowel Disease and Colorectal Cancer
Chapter 7 Extraintestinal Manifestations of Cotton-Top Tamarin Colitis
Chapter 8 A Protocol to Evaluate the Efficacy of Anticolitic Agents Against Ulcerative Colitis in Cotton-Top Tamarins
Chapter 9 Coronaviruses in Tamarin and Marmoset Colitis
Chapter 10 Do Repeated Colonic Mucosal Biopsies Impact Mortality in Cotton-Top Tamarins?
C. Colon Carcinoma in Saguinus oedipus
Chapter 11 Spontaneous Colonic Carcinoma Observations in the Oak Ridge Associated Universities’ 26-Year-Old Cotton-Top Tamarin (Saguinus oedipus) Colony
Chapter 12 Genetic Epidemiology of Colon Cancer
Chapter 13 Prevalence of Colonic Carcinoma in Cotton-Top Tamarin Colonies Throughout the World
Chapter 14 Early Colonic Carcinoma Development in Cotton-Top Tamarins: Evidence of Promotion by Colitic Episodes
Chapter 15 Death Rates with Age from All Causes and from Colonic Carcinoma in Wild-Caught and Colony-Born Cotton-Top Tamarins
Chapter 16 Tamarin Colon Cancer and Flow Cytometry
D. Physiologic Changes and Markers Associated with Colon Disease
Chapter 17 Fecal Steroids in Tamarins and Marmosets
Chapter 18 A Serum Marker for Colon Cancer Detection: The Use of the Cotton-Top Tamarin
Chapter 19 Colonic Glycoprotein Heterogeneity in the Cotton-Top Tamarin: Glycoconjugate Modifications Associated with the Nonhuman Primate Model of Inflammatory Bowel Disease and Colonic Cancer
Chapter 20 Polyamine Metabolism in Colonic Diseases
Chapter 21 Immunobiology of the Cotton-Top Tamarin
Chapter 22 Scintigraphic Imaging of Tamarin Colorectal Cancer with Radiolabeled Monoclonal Antibodies
E. Summary
Chapter 23 Future Directions for Colon Disease Research Using Cotton-Top Tamarins
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