Primary Ovarian Insufficiency A Clinical Guide to Early Menopause 1st Edition by Nanette F. Santoro, Amber R. Cooper – Ebook PDF Instant Download/Delivery: 3319224916, 9783319224916
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ISBN 10: 3319224916
ISBN 13: 9783319224916
Author: Nanette F. Santoro, Amber R. Cooper
Presenting the most current and relevant information on the diagnosis and management of primary ovarian insufficiency, also known as premature ovarian failure (POI/POF), this book presents two equally important voices. The first is the scientific, evidence-based voice discussing the latest information on POI/POF in a concise and logical fashion: etiologies, symptoms, genetics, mechanisms, associated conditions, as well as psychological and lifestyle considerations. The second voice presents the first-person stories of affected women, who are often faced with a diagnosis of irreversible infertility at a very young age and who somehow learn to live with great uncertainty about their ability to create a family – a core identity issue for many women. It is thus not simply a clinical, case-based presentation, but a more collaborative effort between clinicians who are well-versed in the field and women who have POI/POF. Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause will therefore be an excellent practical yet personal reference for OB/GYNs, reproductive medicine specialists, and any clinician, nurse or health care worker treating women living with POI/POF.
Primary Ovarian Insufficiency A Clinical Guide to Early Menopause 1st table of contents:
Chapter 1: Defining Menopause: What Is Early, What Is Late?
Clinical Vignette
Defining Menopause and Primary Ovarian Insufficiency
Symptoms of Menopause and Primary Ovarian Insufficiency
Risk Factors Associated with Early Menopause and POI
POI and Autoimmune Disease
POI and Genetics
Turner Syndrome
Fragile X Syndrome
POI and BRCA1/2 Mutations
POI and Cardiovascular Disease
POI and Cardiovascular Mortality
POI and Stroke
POI and Lipids
POI and Glucose Metabolism
POI and Bone Mineral Density
POI and Cancer
POI and All-Cause Mortality
Conclusion
Key Points
References
Chapter 2: Etiologies of Primary Ovarian Insufficiency
Clinical Vignette
Genetic Causes
FMR (Fragile X Mental Retardation) Gene
Autoimmune Causes
Enzyme Deficiency
Infectious Causes
Latrogenic Causes
Environment and Lifestyle
Radiation
Chemotherapy
Surgery
Conclusion
References
Chapter 3: Signs and Symptoms of Primary Ovarian Insufficiency
Vignettes
Introduction
Diagnosis
Management of Symptoms
Menopause-Like Symptoms
Weight and GI Symptoms
Mindfulness and Mental Fog
Depression
Skin and Hair
Thyroid Disorder and Eye Dryness
Sexual and Urinary Health
Neurological Symptoms
Physical Strength/Weakness and Pain
Circulatory and Metabolic Symptoms
Allergies and Immune System
Infertility and the Consequence of a Traumatic Diagnosis
Energy, Sleep, and Mood
Summary
References
Chapter 4: The Genetics of POI
Patient Vignette
Introduction
Syndromic Causes
Turner Syndrome
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome
Galactosemia
Ataxia Telangiectasia
Progressive External Ophthalmoplegia
Perrault Syndrome
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Ovarian Leukodystrophy
Steroidogenic Enzyme Defects
Werner’s Syndrome
Fanconi’s Anemia
Non-syndromic Causes
Fragile X (FMR1) Premutations
TGFβ (Transforming Growth Factor β) Superfamily
Gonadotropins and Their Receptors
FSH and FSH Receptor
LH and LH Receptor
GnRH (Gonadotropin-Releasing Hormone) and GnRH Receptor
Estrogen Receptor
Progesterone Receptor Membrane Component 1 (PGRMC1)
BRCA1 (Breast Cancer Susceptibility Gene 1)
X Chromosome and POI
Conclusion
References
Chapter 5: Mechanisms of Primary Ovarian Insufficiency
Vignette
Introduction
Disorders of Primordial Follicle Endowment
The X Chromosome and POI
Monosomy X (45,X) Turner Syndrome
Trisomy or Polysomy X
X Chromosome Long Arm (Xq)
X Chromosome Short Arm (Xp)
Autosomal Mutations and POI
Blepharophimosis–Ptosis–Epicanthus Inversus Syndrome
BRCA Mutations
Newborn Ovary Homeobox
LHX8 and NANOS
GDF9 Mutations
Enzyme Deficiencies
Depletion/Destruction of Ovarian Follicles
Ovarian Autoimmunity
Infectious
Toxins, Environmental, and Lifestyle Factors
Treatment (Iatrogenic) Associated Accelerated Follicle Loss
Surgery
Chemotherapy
Radiation
Dysfunction of Ovarian Follicles
Signaling Defects
Conclusion
References
Chapter 6: Nonreproductive Conditions Associated with Primary Ovarian Insufficiency (POI)
Part I: A Patient’s Perspective
Part II: Thyroid Disorders Associated with POI
Part III: Other Nonreproductive Medical Conditions Associated with POI
Part IV: Summary
Part I (reprise)
References
Chapter 7: Noninvasive Approaches to Enhance Ovarian Function
Clinical Vignette
Introduction
Ovulation Induction
Estrogen Priming
GnRH Analogues
Oral Ovulation Induction Agents
Superovulation
Gonadotropins
Alternative Medical Therapies
Corticosteroids
Growth Hormone-Releasing Hormone
Dehydroepiandrosterone
Lifestyle Modifications
Diet and Exercise
Over-the-Counter Supplementation
Smoking Cessation
Coital Frequency
Conclusion
Clinical Vignette
References
Chapter 8: IVF and Egg Donation: Special Considerations
Clinical Vignette
Introduction
IVF in Primary Ovarian Insufficiency
Microdose GnRH Agonist Flare Protocol
GnRH Agonist Stop Protocol
Antagonist Protocol
Clomiphene Citrate and Gonadotropin Protocol
Estrogen Priming
IVF and Growth Hormone
IVF and Dehydroepiandrosterone
IVF and Coenzyme Q10
Laboratory Techniques
In Vitro Maturation
Oocyte Donation
Conclusion
References
Chapter 9: Living with the Uncertainty of Primary Ovarian Insufficiency (POI): A Patient Perspec
Bibliography
Chapter 10: Primary Ovarian Insufficiency (POI) and Mood Disorders
Loss and Grief
Cases
Teenage Onset
Maureen
Turner Syndrome
Sophie: Social Anxiety
Childhood Cancers
Louise
Adult-Onset POI
Eileen: Family Secrets
Cathy: The Unfairness of Life
Fragile X
Lisa
Ann
Adult Cancer and Surgical Patients
Connie
Summary
References
Chapter 11: The Rise and Fall of Oogonial Stem Cells Within the Historical Context of Adult Stem
Clinical Vignette
Introduction
The History of Adult Human Stem Cells and Regenerative Medicine
Germline Stem Cells in Lower Invertebrates
Mammalian Folliculogenesis Is a Complex Process that Involves Maintenance of Meiotic Arrest and
Oogonial Stem Cells: Evidence and Pitfalls
Conclusion
References
Chapter 12: Hormone Replacement Therapy in Women with POI: A Patient’s Perspective
Introduction
The Recommended Approach for Treating POI
Overall Health
Bone Health
Vasomotor and Other Menopausal-Like Symptoms
What About Androgen Replacement?
Options for Women and Their Clinicians
A Closer Look at Bone Density
Remaining Questions on Health Impacts and Contraindications
A Caring, Empowering Approach
HRT and Life Stage
Age 50 and Over
Adolescence
With Pregnancy
Associations with Sexual Function and Communicating with Partners
More to Treating POI than HRT
Conclusion
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