Personalized medicine 1st Edition by Donev Rossen 0128047958 9780128047958

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Product details:

ISBN 10: 0128047958 

ISBN 13: 9780128047958

Author: Donev Rossen 

Personalized medicine 1st Table of contents:

Chapter One: High-Performance Affinity Chromatography: Applications in Drug–Protein Binding Studies and Personalized Medicine
Abstract
1 Introduction
2 Frontal Analysis Studies of Drug–Protein Interactions
3 Zonal Elution Studies of Drug–Protein Interactions
4 Other Methods for Examining Drug–Protein Interactions
5 Conclusion
Acknowledgments
Chapter Two: Role of Proteomics in the Development of Personalized Medicine
Abstract
1 Introduction
2 Protein Biomarkers
3 Protein Biochips
4 Role of Proteomics-Based Molecular Diagnostics in Personalized Medicine
5 Pharmacoproteomics
6 Concluding Remarks About Application of Proteomics for Personalized Medicine
Chapter Three: Metabolomics and Personalized Medicine
Abstract
1 Introduction
2 The Value of “Omics” Technologies in the Development of Personalized Medicine
3 What is Metabolomics?
4 The Application of Metabolomics Toward Personalized Medicine
5 Concluding Remarks
Acknowledgments
Chapter Four: Clinical Perspectives on Targeting Therapies for Personalized Medicine
Abstract
1 Introduction
2 What Are Personalized Medicines?
3 Rare Diseases
4 Evidence for Precision Medicines from Real World Data
5 Using “Real World” Data
6 Ethical Concerns
7 Adaptive Trial Design
8 Companion Diagnostics
9 Biological Treatments
10 Case Studies: Targets for Precision Medicines and Companion Diagnostics
11 Network Pharmacology
12 Future Developments
Acknowledgments
Chapter Five: Personalized Medicine in Respiratory Disease: Role of Proteomics
Abstract
1 Introduction
2 Personalized Medicine
3 Proteomics
4 Respiratory Proteomics
5 Asthma
6 Chronic Obstructive Pulmonary Disease
7 Idiopathic Pulmonary Fibrosis
8 Aspirin-Exacerbated Respiratory Disease
9 Cystic Fibrosis
10 Lung Cancer
11 Conclusions
Acknowledgments
Chapter Six: Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop
Abstract
1 Introduction
2 Currently Approved Products Targeting Protein Kinases in Oncology
3 Tumor Heterogeneity
4 Computational Methods for Identifying Driver Mutations
5 Literature Mining in Oncology Research
6 Precise Genome Editing
7 Conclusion
Supplementary Material
Chapter Seven: Molecular Dynamics: New Frontier in Personalized Medicine
Abstract
1 Introduction
2 Single Nucleotide Polymorphisms in Drug Response
3 Drug Discovery
4 Advent of Personalized Medicine
5 Evolution of Molecular dynamics in the Field of Macromolecule and Binding Interaction Analysis
6 Molecular Dynamics—A Boon in Personalized Medicine
7 MD Trajectories Analysis
8 Application of MD in SNP Analysis Toward Drug Discovery
9 Plausible Ways to Overcome the Disadvantages of Molecular Dynamics
10 Conclusion
Acknowledgments
Chapter Eight: Personalized Pharmacoperones for Lysosomal Storage Disorder: Approach for Next-Generation Treatment
Abstract
1 Introduction
2 LSDs Classification
3 Treatment of LSDs
4 Pharmacological Chaperones Versus Chemical Chaperones
5 Combination Therapy for LSDs
6 How Can PCT Personalized?
7 Computational Studies in PCT
8 Advantages and Disadvantages of Various Therapies in LSDs
9 Future of PCTs
10 Conclusion
Acknowledgments
Chapter Nine: Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at Codon 1047 of PIK3CA Kinase Domain: A Molecular Docking and Molecular Dynamics Approach
Abstract
1 Introduction
2 Materials and Methods
3 Results
4 Discussion
5 Conclusion
Acknowledgments
Chapter Ten: Role of von Willebrand Factor—A1 Domain Variants P1266L, H1268D, C1272R, and C1272F in VWD: A Molecular Modeling and Simulation Analysis Approach
Abstract
1 Introduction
2 Material and Methods
3 Results
4 Discussion
5 Conclusion

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Tags: Personalized medicine, Donev Rossen, Protein Chemistry, Structural Biology