Molecular Signaling in Spermatogenesis and Male Infertility First Edition Rajender 0429534426 9780429534423

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Product details:

• ISBN-10 ‏ : ‎ 0429534426
• ISBN-13 ‏ : ‎ 9780429534423
• Author: Rajender Singh

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Table of contents:

1. Primordial germ cells: Origin, migration and testicular development

2. DNA methylation, imprinting and gene regulation in germ cells

3. Testicular stem cells, spermatogenesis and infertility

4. Testicular germ cell apoptosis and spermatogenesis

5. Hormonal regulation of spermatogenesis

6. GH–IGF1 axis in spermatogenesis and male fertility

7. Retinoic acid signaling in spermatogenesis and male (in)fertility

8. Testosterone signaling in spermatogenesis, male fertility and infertility

9. Wnt signaling in spermatogenesis and male infertility

10. MAPK signaling in spermatogenesis and male infertility

11. TGF-β signaling in testicular development, spermatogenesis, and infertility

12. Notch signaling in spermatogenesis and male (in)fertility

13. Hedgehog signaling in spermatogenesis and male fertility

14. mTOR signaling in spermatogenesis and male infertility

15. JAK-STAT pathway: Testicular development, spermatogenesis and fertility

16. PI3K signaling in spermatogenesis and male infertility

17. Spermatogenesis, heat stress and male infertility

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