Goldman Cecil Medicine 26th Edition by Lee Goldman 9780323532662 0323532667
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ISBN 10:0323532667
ISBN 13: 9780323532662
Author:Lee Goldman
To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature.
But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.
- More than 400 chapters authored by a veritable “Who’s Who” of modern medicine
- A practical, templated organization with an emphasis on evidence-based references
- Thousands of algorithms, figures, and tables that make its information readily accessible
- Over 90 supplementary videos, heart sounds, and key references
- Available in print and on a variety of electronic devices
- Supplemened by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations
- Continuously updated by Lee Goldman, MD
- Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
Goldman Cecil Medicine 26th Table of contents:
Section I. Social and Ethical Issues in Medicine
1. Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession
Approach to Medicine
Approach to the Patient
Approach to the Medical Profession
General References
2. Bioethics in the Practice of Medicine
Physician-Patient Relationship: Informed Consent
Termination of Medical Interventions
Assisted Suicide and Euthanasia
Financial Conflicts of Interest
Future Directions
Grade A References
General References
Review Questions
3. Palliative Care
Palliative Care Domains
Grade A References
General References
Review Questions
4. Disparities in Health and Health Care
Definitions of Health Disparity and Health Equity
Demographic Changes in U.S. Population
Racial and Ethnic Disparities in Health Outcomes
Socioeconomic Disparities in Health Outcomes
Insurance Coverage and Access to Care
Quality of Care
Clinical Approaches to Reduce Disparities
Grade A Reference
General References
Review Questions
5. Global Health
What Is Global Health?
Global Burden of Diseases
Changing Patterns of Diseases
Grade A References
General References
Review Questions
Section II. Principles of Evaluation and Management
6. Approach to the Patient: History and Physical Examination
Overview
Medical History
Physical Examination
Summarizing the Findings for the Patient
Future Directions
General References
Review Questions
7. Approach to the Patient with Abnormal Vital Signs
The Importance of Vital Signs
Measuring Vital Signs
Role of Vital Signs in Management of the Patient
General References
Review Questions
8. Statistical Interpretation of Data and Using Data for Clinical Decisions
Incidence and Prevalence
Interpreting Data
Data and Their Characteristics
Hypothesis Testing
Causality
Statistical Approaches and Challenges
Using Data for Clinical Decisions
General References
Review Questions
9. Measuring Health and Health Care
How are Health and Health Care Measured?
Why Measure Health and Health Care?
Selecting Measures Based on Evidence
Selecting Measures: Which Measures are Right for What Purpose?
Measuring Health and Health Care as Parts of a System
General References
10. Quality, Safety, and Value
Quality
Patient Safety
Quality and Safety During a Pandemic
Value: Connecting Safety and Quality to Cost
Grade A References
General References
Review Questions
11. Comprehensive Chronic Disease Management
The Goals of Chronic Care Management
Matching Patient Needs and Care Delivery
Transforming Practice
Grade A References
General References
Review Questions
Section III. Preventive and Environmental Issues
12. The Periodic Health Examination
History and Risk Assessment
Screening for Early Disease or Asymptomatic Risk Factors
Behavioral Interventions
Immunizations
Chemoprevention and Supplements
Future Issues
Grade A References
General References
Review Questions
13. Physical Activity
Grade A References
General References
Review Questions
14. Adolescent Medicine
Normal Physical Growth and Development
Normal Psychosocial Development
Vital Statistics
Approach to the Adolescent Patient
Sexual and Reproductive Health
Obesity
Mental Health
Chronic Illness and Transition
Grade A References
General References
Review Questions
15. Immunization
General Characteristics of Immunizations
Individual Immunobiologics
Vaccines Intended Primarily for International Travelers
Vaccines for Possible Bioterrorism Agents
Other Vaccines
Grade A References
General References
Review Questions
16. Principles of Occupational and Environmental Medicine
Principles of Occupational and Environmental Disease
Occupational and Environmental Health Disorders Common in Practice
Common Hazardous Exposures in the Workplace and Ambient Environment
Summary
Grade A References
General References
Review Questions
17. Radiation Injury
Ionizing Radiation
Non-Ionizing Radiation Injury
Grade A References
General References
Review Questions
18. Bioterrorism
History
Epidemiologic Clues
Agents of Concern
Anthrax
Smallpox
Plague
Tularemia
Botulism
Viral Hemorrhagic Fevers
Response to a Bioterrorism Attack
Grade A References
General References
Review Questions
19. Chronic Poisoning: Trace Metals and Others
Lead Toxicity
Mercury Toxicity
Arsenic Toxicity
Cadmium Toxicity
Syndromes Specific to Other Toxic Metals
Grade A References
General References
Review Questions
Section IV. Aging and Geriatric Medicine
20. Epidemiology of Aging: Implications of an Aging Society
Demography
The Health of Older Adults
Prevention
Grade A References
General References
Review Questions
21. Geriatric Assessment
Functional Status
Prognosis
Patient Goals
Components of Geriatric Assessment
Preventive Services
Nonmedical Assessments
A Strategic Approach to Geriatric Assessment for the Practicing Clinician
Grade A References
General References
Review Questions
22. Common Clinical Sequelae of Aging
Effects of Aging on Specific Organs and Systems
Grade A References
General References
Review Questions
23. Urinary Incontinence
Grade A References
General References
Review Questions
24. Neuropsychiatric Aspects of Aging
Grade A References
General References
Review Questions
25. Delirium in the Older Patient
Delirium
Grade A References
General References
Review Questions
Section V. Clinical Pharmacology
26. Principles of Drug Therapy
Pharmacokinetic Principles
Clinical Application of Pharmacokinetic Principles
Drug Monitoring as a Guide to Therapy
Adjustments of Drug Dose With Disease
Approach to Drug Overdose
Drug Use in Elderly Patients
Interactions Between Drugs
Adverse Reactions to Drugs
Genomic Data Providing Guidance for Cancer Therapeutic Decision
Grade A References
General References
Review Questions
27. Pain
Grade A References
General References
28. Biology of Addiction
Risk Factors for Addiction
Reward Circuitry: the Neural Substrate of Addiction
Properties of Addictive Drugs
Drug-Induced Neural Plasticity Relevant to Addiction
General References
Review Questions
29. Nicotine and Tobacco
Grade A References
General References
Review Questions
30. Alcohol Use Disorders
Grade A References
General References
Review Questions
31. Drugs of Abuse
Major Drugs of Abuse
Conclusions and Future Directions
Grade A References
General References
Review Questions
32. Immunomodulatory Drugs
Glucocorticoids
Immunomodulatory Agents
Immunosuppressive Agents
Purine and Pyrimidine Inhibitors
Immunophilin-Binding Agents Including Calcineurin Inhibitors
Alkylating Agent
Grade A Reference
General References
Review Questions
33. Biologic Agents and Signaling Inhibitors
Biologic Agents
Conclusion
Grade A References
General References
34. Complementary, Alternative, and Integrative Medicine
Use of Integrative, Complementary, and Alternative Treatments
Mind and Body Practices
Natural Products
Conclusions
Grade A References
General References
Review Questions
Section VI. Genetics
35. Principles of Genetics
Genetic Contribution to Disease
Conclusion
General References
Review Questions
36. Clinical Genomics—Genome Structure and Variation
Clinical Genomics
Gene
Genomic Variation in Humans
Assaying Genetic Variation
Genetic Test Reports
Genomics and Genetics as a Normal Part of Medicine
Conclusion
General References
37. Applications of Molecular Technologies to Clinical Medicine
Molecular Technologies Along the Continuum From Health to Disease
Genomes, Disease, and Treatment
The Expressed Genome
Implementing Precision Medicine in Clinical Practice
General References
38. Regenerative Medicine, Cell, and Gene Therapies
Cell Therapy
Cell Therapy in the Treatment of Cancer
Gene Therapy
Grade A References
General References
Review Questions
Section VII. Principles of Immunology and Inflammation
39. The Innate Immune System
The Innate Immune System in Host Defense and Disease Pathogenesis
General References
Review Questions
40. The Adaptive Immune System
Principles of Adaptive Immune System Activation: Recognition of Antigen
Cellular Elements of the Adaptive Immune System
General References
Review Questions
41. Mechanisms of Immune-Mediated Tissue Injury
The Adaptive Immune Response
Hypersensitivity Reactions
General References
Review Questions
42. Mechanisms of Inflammation and Tissue Repair
The Inflammatory Response
Grade A Reference
General References
43. Transplantation Immunology
Antigens in Transplantation
Mechanisms of Rejection and Graft-Versus-Host Disease
Strategies to Prevent Graft-Versus-Host Disease
Strategies to Prevent Allograft Rejection
Grade A References
General References
44. Complement System in Disease
Activation of Complement
Complement Inhibitors
General References
Section VIII. Cardiovascular Disease
45. Approach to the Patient with Possible Cardiovascular Disease
Using the History to Detect Cardiovascular Symptoms
Physical Examination for Detection of Signs of Cardiovascular Disease
Summary
Grade A References
General References
46. Epidemiology of Cardiovascular Disease
Burden in the United States
Global Burden
Risk Factors for Cardiovascular Disease
Grade A References
General References
47. Cardiac and Circulatory Function
Structure of the Heart
Anatomy of the Heart
Physiology of the Heart and Circulatory Control
Cardiovascular Responses to Stressors
Impaired Circulatory Function: Atherosclerosis
Grade A References
General References
Review Questions
48. Electrocardiography
Normal Function and Electrocardiogram
Approach to Interpreting the Electrocardiogram
Grade A References
General References
49. Echocardiography
Echocardiographic Imaging
Doppler Echocardiography
Echocardiographic Approaches
Cardiac Function Measurements
The Echocardiographic Examination
Integrating the Echocardiographic and Clinical Findings
Grade A References
General References
Review Questions
50. Noninvasive Cardiac Imaging
Radiography of the Heart
Nuclear Cardiology
Cardiac Computed Tomography
Cardiovascular Magnetic Resonance Imaging
Grade A References
General References
Review Questions
51. Catheterization and Angiography
Indications for and Contraindications to Cardiac Catheterization
The Catheterization Procedure
Coronary Angiography
Complications of Cardiac Catheterization
Hemodynamic Data Obtained During Cardiac Catheterization
Additional Procedures Performed in the Catheterization Laboratory
Structural Heart Disease Interventions
Grade A References
General References
Review Questions
52. Heart Failure: Pathophysiology and Diagnosis
Consequences of Misdiagnosis
Grade A References
General References
Review Questions
53. Heart Failure: Management and Prognosis
Evaluation and Management of Heart Failure
Stages of Heart Failure
Future Directions
Grade A References
General References
54. Diseases of the Myocardium and Endocardium
Myocardial Disease
Diseases of the Endocardium
Cardiac Tumors
Grade A References
General References
Review Questions
55. Principles of Electrophysiology
Basic Concepts
Ionic Basis of Cardiac Electrophysiology
Molecular Basis of Cardiac Electrophysiology
Mechanisms of Arryhthmogenesis
Summary
General References
56. Approach to the Patient with Suspected Arrhythmia
Grade A References
General References
Review Questions
57. Approach to Cardiac Arrest and Life-Threatening Arrhythmias
Grade A References
General References
Review Questions
58. Supraventricular Cardiac Arrhythmias
Anatomy and Normal Electrophysiology
Bradyarrhythmias
Grade A References
General References
Review Questions
59. Ventricular Arrhythmias
Grade A References
General References
60. Electrophysiologic Interventional Procedures and Surgery
Transthoracic Cardioversion and Defibrillation
Cardiac Implantable Electronic Devices
Catheter Ablation
Arrhythmia Surgery
Grade A References
General References
Review Questions
61. Congenital Heart Disease in Adults
Simple Lesions
Specific Complex Lesions
Grade A References
General References
Review Questions
62. Angina Pectoris and Stable Ischemic Heart Disease
Other Anginal Syndromes
Grade A References
General References
63. Acute Coronary Syndrome: Unstable Angina and Non–ST Elevation Myocardial Infarction
Grade A References
General References
Review Questions
64. ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction
Grade A References
General References
Review Questions
65. Interventional and Surgical Treatment of Coronary Artery Disease
Percutaneous Coronary Intervention
Coronary Angioplasty Versus Medical Therapy
Coronary Artery Surgery
Indications for Bypass Surgery
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting
Grade A References
General References
Review Questions
66. Valvular Heart Disease
Aortic Stenosis
Mitral Stenosis
Primary (Organic) Mitral Regurgitation
Mitral Valve Prolapse
Secondary (Functional) Mitral Regurgitation
Aortic Regurgitation
Tricuspid Regurgitation
Pulmonic Stenosis
Grade A References
General References
Review Questions
67. Infective Endocarditis
Grade A References
General References
Review Questions
68. Pericardial Diseases
Acute Pericarditis
Pericardial Effusion and Tamponade
Pericardial Constriction
Specific Forms of Pericardial Disease
Grade A References
General References
Section IX. Vascular Medicine
69. Diseases of the Aorta
Aortic Aneurysms
Intramural Aortic Hematoma and Aortic Dissection
Takayasu Arteritis
Giant Cell Arteritis
Grade A References
General References
70. Arterial Hypertension
Primary Aldosteronism
Renal Parenchymal Hypertension
Renovascular Hypertension
Mendelian Forms of Mineralocorticoid-Induced Hypertension
Pheochromocytoma and Paraganglioma
Other Neurogenic Causes
Other Causes of Secondary Hypertension
Grade A References
General References
Review Questions
71. Atherosclerotic Peripheral Arterial Disease
Grade A References
General References
Review Questions
72. Other Peripheral Arterial Diseases
Popliteal Artery Entrapment Syndrome
Cystic Adventitial Disease of the Lower Extremity Arteries
Endofibrosis of the Iliac Artery
Fibromuscular Dysplasia
Thromboangiitis Obliterans (Buerger Disease)
Livedo Reticularis
Atheromatous Embolization
Thermal Disorders
Grade A References
General References
73. Thrombotic Disorders: Hypercoagulable States
Primary Hypercoagulable States
Secondary Hypercoagulable States
Grade A References
General References
Review Questions
74. Venous Thrombosis and Embolism
Long-Term Complications of VTE
Venous Thrombosis of the Upper Extremities
Superficial Vein Thrombosis
Prevention of VTE
Nonthrombotic Pulmonary Embolism
Grade A References
General References
Review Questions
75. Pulmonary Hypertension
Grade A References
General References
Review Questions
76. Antithrombotic and Antiplatelet Therapy
Anticoagulant Agents
Grade A References
General References
Review Questions
Section X. Respiratory Diseases
77. Approach to the Patient with Respiratory Disease
Approach to the Patient With Cough
Approach to the Patient With Wheezing
Approach to the Patient With Dyspnea
Approach to the Patient With Hemoptysis
Grade A References
General References
Review Questions
78. Imaging in Pulmonary Disease
Imaging of the Lungs, Mediastinum, and Chest Wall
Imaging of the Mediastinum
General References
Review Questions
79. Respiratory Testing and Function
Spirometry
Other Tests of Ventilation
Reference Equations
Lung Volumes
Diffusing Capacity
Maximal Respiratory Pressures
Interpretation of Lung Function Tests
Provocative Testing
Cardiopulmonary Exercise Tests
Bronchoalveolar Lavage
Complex Disorders
Pulmonary Function in Obesity
General References
Review Questions
80. Disorders of Ventilatory Control
Hypoventilation Syndromes
Grade A References
General References
Review Questions
81. Asthma
Grade A References
General References
Review Questions
82. Chronic Obstructive Pulmonary Disease
Acute Exacerbations of COPD
Grade A References
General References
Review Questions
83. Cystic Fibrosis
Grade A References
General References
84. Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders
Bronchiectasis
Atelectasis
Congenital Cystic Diseases of the Thorax
Acquired Cystic Lung Diseases
Grade A References
General References
Review Questions
85. Alveolar Filling Disorders
Pulmonary Alveolar Proteinosis
Acute Interstitial Pneumonia
Diffuse Alveolar Hemorrhage
Invasive Mucinous Adenocarcinoma and Lepidic Predominant Nonmucinous Adenocarcinoma (Formerly Called Bronchioloalveolar Cell Carcinoma)
Grade A References
General References
Review Questions
86. Interstitial Lung Disease
Specific Types of Interstitial Lung Disease
Grade A References
General References
Review Questions
87. Occupational Lung Disease
Specific Occupational Lung Disorders
Occupational Chronic Obstructive Pulmonary Disease
Hypersensitivity Pneumonitis
Chronic Beryllium Disease
Asbestos-Related Diseases
Silicosis and Other Pneumoconioses
Acute Febrile Syndromes
Occupational Lung Cancer
General References
Review Questions
88. Physical and Chemical Injuries of the Lung
Submersion Incidents: Drowning
Diseases of High Altitude
Decompression Illness: Decompression Sickness, Barotrauma, and Arterial Gas Embolism
Inhalation Injuries
Oxygen Toxicity
Lung Injury
Grade A References
General References
Review Questions
89. Sarcoidosis
Grade A References
General References
Review Questions
90. Acute Bronchitis and Tracheitis
Grade A References
General References
Review Questions
91. Overview of Pneumonia
Aspiration Pneumonia
Hospital-Acquired Pneumonia, Ventilator-Associated Pneumonia, and Health Care–Associated Pneumonia
Grade A References
General References
Review Questions
92. Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum
Diaphragm
Chest Wall
Pleura
Mediastinum
Grade A References
General References
Review Questions
93. Interventional and Surgical Approaches to Lung Disease
Bronchoscopy
Surgery for Benign Lung Disease
Surgery for Advanced Lung Diseases: Lung Volume Reduction Surgery
Endoscopic Management of Emphysema
Lung Transplantation
Grade A References
General References
Review Questions
Section XI. Critical Care Medicine
94. Approach to the Patient in a Critical Care Setting
The Intensivist-Led Interprofessional Team
Fluid Resuscitation and Acute Kidney Injury
Sedation, Analgesia, Infection, Fever Control, Oxygen Administration, and Intravenous Access
Spontaneous Breathing Trials
Long-Term Outcomes for Survivors
Applying Evidence to Prevent Complications of Critical Illness
Predictions, Preferences, and Palliative Care
Grade A References
General References
Review Questions
95. Respiratory Monitoring in Critical Care
Physical Examination
Systemic Arterial Blood Gas Analysis
Pulse Oximetry
Carbon Dioxide Monitoring: Capnometry and Transcutaneous Carbon Dioxide Measurement
Arterial Oxygen Content and Systemic Oxygen Delivery
Measuring Ventilation: Minute Ventilation and Alveolar Ventilation
Measuring Carbon Dioxide Production
Measuring Respiratory Compliance
Measuring Respiratory Drive
Measuring Respiratory Muscle Strength
Measuring Work of Breathing
Grade A References
General References
Review Questions
96. Acute Respiratory Failure
Specific Acute Respiratory Failure Syndromes
Grade A References
General References
97. Mechanical Ventilation
Types of Mechanical Ventilators
Complications of Mechanical Ventilation
Specific Common Treatment Scenarios
Discontinuation of Mechanical Ventilation
Grade A References
General References
Review Questions
98. Approach to the Patient with Shock
Grade A References
General References
Review Questions
99. Cardiogenic Shock
Grade A References
General References
Review Questions
100. Shock Syndromes Related to Sepsis
Grade A References
General References
Review Questions
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