A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment 1st Edition Natàlia Garcia-Reyero 3319660845 9783319660844

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Product details:

• ISBN 10: 3319660845
• ISBN 13: 9783319660844
• Author: Natàlia Garcia-Reyero

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

Table of contents:

1. Advancing Adverse Outcome Pathways for Risk Assessment

2. Use of High-Throughput and Computational Approaches for Endocrine Pathway Screening

3. Cell-Free Assays in Environmental Toxicology

4. The Fish Embryo as a Model for AOP Development

5. Invertebrate Model Species in AOP Development

6. Non-model Species in Ecological Risk Assessment

7. Green Algae and Networks for Adverse Outcome Pathways

8. Neurobehavioral Analysis Methods for Adverse Outcome Pathway (AOP) Models and Risk Assessment

9. The Application of Omics Data to the Development of AOPs

10. Use of Genetic Manipulation for Evaluating and Understanding Adverse Outcome Pathways

11. Considering Epigenetics in Adverse Outcome Pathways

12. Tiered Approaches to Incorporate the Adverse Outcome Pathway Framework into Chemical-Specific Risk-Based Decision Making

13. The Development of Quantitative AOPs

14. Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model

15. Weight of Evidence Frameworks in Evaluation of Adverse Outcome Pathways

16. Using a Vitellogenesis Model to Link in vitro Neurochemical Effects of Pulp and Paper Mill Effluents to Adverse Reproductive Outcomes in Fish

17. Use of Adverse Outcome Pathways in Human Risk Assessment and Toxicology

18. Use and Acceptance of AOPs for Regulatory Applications

19. The Future of Adverse Outcome Pathways: Analyzing their Social Context

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