Actin Cytoskeleton in Cancer Progression and Metastasis, Part C 1st Edition Clément Thomas 0128212829 9780128212820

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Product details:

• ISBN 10: 0128212829
• ISBN 13: 9780128212820
• Author: Clément Thomas

Actin Cytoskeleton in Cancer Progression and Metastasis – Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response.

Table of contents:

1: Introduction

2: The paxillin family

3: Fundamentals of cell migration

4: Roles of paxillin and Hic-5 in regulating migration and invasion

5: Stroma-mediated effects on tumor invasion

6: Regulation of gene expression

7: Paxillin family member mutations and expression in human cancers

8: Therapeutic potential

9: Conclusion

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