Acute Neuronal Injury The Role of Excitotoxic Programmed Cell Death Mechanisms Denson G. Fujikawa

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Product details:

• ISBN-10 ‏ : ‎ 9783319774947
• ISBN-13 ‏ : ‎ 978-3319774947
• Author:  Denson G. Fujikawa

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.
The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

Table of contents:

1. Caspase-Independent Programmed Cell Death: General Considerations

1. Introduction

2. Caspase-Independent Cell Death Mechanisms in Simple Animal Models

3. Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons?

4. Age-Dependence of Neuronal Apoptosis and of Caspase Activation

5. Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

2. Focal Cerebral Ischemia

6. Significant Role of Apoptosis-Inducing Factor (AIF) for Brain Damage Following Focal Cerebral Ischemia

7. The Role of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Activation in Focal Cerebral Ischemia

3. Transient Global Ischemia

8. Transient Global Cerebral Ischemia Produces Morphologically Necrotic, Not Apoptotic Neurons

9. Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia

10. Role of µ-Calpain I and Lysosomal Cathepsins in Hippocampal Neuronal Necrosis After Transient Global Ischemia in Primates

4. Traumatic Central Nervous System (CNS) Injury

11. Mitochondrial Damage in Traumatic CNS Injury

12. Programmed Neuronal Cell Death Mechanisms in CNS Injury

5. Hypoglycemic Neuronal Death

13. Hypoglycemic Brain Damage

14. Hypoglycemic Neuronal Death

6. Seizure-Induced Neuronal Death

15. Tumor Suppressor p53: A Multifunctional Protein Implicated in Seizure-Induced Neuronal Cell Death

16. DNA Damage and Repair in the Brain: Implications for Seizure-Induced Neuronal Injury, Endangerment, and Neuroprotection

17. Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis

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