Acute Promyelocytic Leukemia 1st Edition by Oussama Abla, Francesco Lo Coco, Miguel A Sanz ISBN 3030097137 978-3030097134

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ISBN 10: 3030097137 

ISBN 13: 978-3030097134 

Author: Oussama Abla, Francesco Lo Coco, Miguel A. Sanz

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.

Table of contents: 

1. History of Acute Promyelocytic Leukemia
2. Molecular Targets of Treatment in APL
3. The Leukemic Stem Cell
4. Molecular Genetics of APL
5. APL Coagulopathy
6. Early Death in APL
7. Prognostic Factors in APL
8. First-Line Therapy for APL: Chemotherapy-Based Approach
9. First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach
10. Cure of APL Without Chemotherapy
11. Minimal Residual Disease in APL
12. Treatment of Refractory and Relapsed APL
13. Hematopoietic Stem Cell Transplantation in APL
14. APL in Children
15. Management of APL in the Elderly
16. Special Situations in APL
17. APL in Developing Countries: A Chemotherapy-Based Approach
18. APL in Developing Countries: ATO-Based Approach
19. Therapy-Related Acute Promyelocytic Leukemia
20. Rare Acute Leukemia Variants Involving Retinoic Acid Receptor Genes
21. Management of Treatment-Related Complications in APL

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Oussama Abla,Francesco Lo Coco,Miguel A Sanz,Acute Promyelocytic Leukemia