Atomic Force Microscopy in Molecular and Cell Biology Jiye Cai

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• Author: Jiye Cai

The book addresses new achievements in AFM instruments – e.g. higher speed and higher resolution – and how AFM is being combined with other new methods like NSOM, STED, STORM, PALM, and Raman. This book explores the latest advances in atomic force microscopy and related techniques in molecular and cell biology. Atomic force microscopy (AFM) can be used to detect the superstructures of the cell membrane, cell morphology, cell skeletons and their mechanical properties.

Opening up new fields of in-situ dynamic study for living cells, enzymatic reactions, fibril growth and biomedical research, these combined techniques will yield valuable new insights into molecule and cell biology. This book offers a valuable resource for students and researchers in the fields of biochemistry, cell research and chemistry etc.

Table of contents:

1. Principles of Atomic Force Microscopy

2. Atomic Force Microscopy-Based Single Molecule Force Spectroscopy for Biological Application

3. In Situ Single Molecule Detection on Cell Membrane and Label Molecule Distributions Using AFM/NSOM

4. AFM Imaging-Force Spectroscopy Combination for Molecular Recognition at the Single-Cell Level

5. Atomic Force Microscopy: A Nanoscopic Application in Molecular and Cell Biology

6. The Hyphenated Technique of High Speed Atomic Force Microscopy and Super Resolution Optical Detection System

7. AFM and NSOM/QD Based Direct Molecular Visualization at the Single-Cell Level

8. Assessment of Pathological or Drug-Dependent Changes in Cell Membrane Morphology and Cell Biomechanical Properties by Atomic Force Microscopy

9. In Situ Measuring Mechanical Properties of Normal and Disease Cells

10. High Resolution AFM and Its Applications

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