Cancer Systems Biology Methods and Protocols 1st Edition by Louise Von Stechow ISBN 1493974920 9781493974924

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ISBN 10:      1493974920
ISBN 13: 978- 1493974924
Author:     Louise Von Stechow

This book comprises protocols describing systems biology methodologies and computational tools, offering a variety of ways to analyze different types of high-throughput cancer data. Chapters give an overview over data types available in large-scale data repositories and state-of-the-art methods used in the field of cancer systems biology.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Cancer Systems Biology : Methods and Protocols aims to ensure successful results in the further study of this vital field.

The chapters “Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels”, “Perseus: A Bioinformatics Platform for Integrative Analysisof Proteomics Data in Cancer Research” and “Phosphoproteomics-based Profiling of Kinase Activities in Cancer Cells” are available open access under a CC BY 4.0 license via link.springer.com.

Cancer Systems Biology Methods and Protocols 1st Table of contents:

• Chapter 1: Cancer Genomics

  • The Role of Genomic Data in Cancer
  • Next-Generation Sequencing Techniques
  • Bioinformatics Tools for Cancer Genomics
  • Case Studies: Identifying Cancer Driver Mutations

• Chapter 2: Cancer Transcriptomics

  • RNA Sequencing (RNA-Seq) in Cancer
  • Analysis of Gene Expression Profiles
  • Differential Gene Expression and Cancer Pathogenesis
  • Methods for Quantifying Non-coding RNA

• Chapter 3: Cancer Proteomics

  • The Proteome and Cancer
  • Mass Spectrometry in Proteomics
  • Quantitative Proteomics for Cancer Biomarker Discovery
  • Challenges in Cancer Proteomics

• Chapter 4: Cancer Metabolomics

  • Metabolomic Profiling in Cancer
  • Analytical Techniques for Metabolomics
  • Linking Metabolomics with Cancer Progression
  • Cancer Metabolism and Therapeutic Implications

• Chapter 5: Cancer Epigenomics

  • Epigenetic Mechanisms in Cancer
  • Techniques for Studying DNA Methylation
  • Chromatin Remodeling and Cancer Development
  • The Role of Histone Modifications in Cancer

• Chapter 6: Cancer Microbiomics

  • The Human Microbiome and Cancer
  • Methods for Microbiome Analysis in Cancer
  • The Impact of the Gut Microbiome on Cancer
  • Cancer and Host-Microbe Interactions

• Chapter 7: Computational Modeling in Cancer Systems Biology

  • Introduction to Computational Models
  • Network-Based Approaches to Cancer Systems Biology
  • Mathematical Modeling of Cancer Growth
  • Simulation of Cancer Pathways and Drug Response

• Chapter 8: Systems Pharmacology and Cancer Therapy

  • Overview of Systems Pharmacology
  • Drug Discovery and Cancer Treatment Response
  • Modeling Drug Interaction Networks
  • Personalizing Cancer Therapy Using Systems Biology

• Chapter 9: Cancer Systems Biology and Precision Medicine

  • Integrating Omics Data for Precision Medicine
  • Approaches for Tailoring Cancer Treatment
  • Biomarkers for Predicting Cancer Outcomes
  • Challenges and Future Directions in Cancer Precision Medicine

• Chapter 10: Cancer Systems Biology in Clinical Research

  • Translating Systems Biology to Clinical Applications
  • Integrating Multi-Omics Data for Cancer Diagnosis
  • Systems Approaches to Cancer Prognosis and Prediction
  • The Role of Clinical Trials in Cancer Systems Biology

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