Cell Biology and Translational Medicine Volume 8 Stem Cells in Regenerative Medicine 1st edition by Kursad Turksen ISBN 303045892X 9783030458928

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ISBN 10:    303045892X
ISBN 13: 978-3030458928
Author:      Kursad Turksen

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.

This book series ‘Cell Biology and Translational Medicine (CBTMED)’ as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eight volume of a continuing series.

Cell Biology and Translational Medicine Volume 8 Stem Cells in Regenerative Medicine 1st Table of contents:

1. The Future of Stem Cell Research and its Clinical Translation in Canada: Exploring Questions of Governance and Policy Options

• Focus: Addressing the ethical, regulatory, and policy challenges related to stem cell research in Canada, including questions of governance.
• Potential Impact: Ensuring safe and efficient translation of stem cell therapies from the lab to clinical use.

2. Future Cell and Gene Therapy for Osteoarthritis (OA)

• Focus: Using mammalian protein production platforms, irradiated, and transfected protein packaging cell lines for overproduction of therapeutic proteins and growth factors.
• Potential Impact: Development of advanced cell and gene therapies to treat osteoarthritis, with potential to reduce pain and regenerate cartilage in affected joints.

3. The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges

• Focus: Progress in gene therapy techniques, including targeted gene editing and delivery mechanisms.
• Potential Impact: Addressing genetic disorders, chronic diseases, and personalized medicine through gene-based therapies, though challenges in delivery and safety still remain.

4. Developments in Artificial Platelet and Erythroid Transfusion Products

• Focus: Advances in the development of artificial blood products, particularly platelets and red blood cells, for transfusion medicine.
• Potential Impact: Reducing reliance on donor blood, improving the availability of transfusion products, and creating alternatives for patients with blood disorders or trauma.

5. Advancing Mesenchymal Stem Cell Therapy with CRISPR/Cas9 for Clinical Trial Studies

• Focus: Using CRISPR/Cas9 gene-editing technology to enhance the therapeutic potential of mesenchymal stem cells.
• Potential Impact: Development of more effective stem cell-based therapies, particularly for autoimmune diseases, injury recovery, and chronic conditions, with precision medicine applications.

6. Mesenchymal Stem Cells in Asthma

• Focus: Investigating the potential of mesenchymal stem cells as a therapeutic option for asthma, focusing on immunomodulation and lung tissue repair.
• Potential Impact: Providing new avenues for treating asthma, potentially reducing inflammation and improving lung function in chronic asthma patients.

7. Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility

• Focus: Understanding how aging impacts oocyte (egg) quality and fertility, and the environmental factors that contribute to oocyte aging.
• Potential Impact: Insights into fertility preservation techniques, including improving assisted reproductive technologies (ART) and delaying the effects of aging on female fertility.

8. Targeting Cancer Metabolism and Cell Cycle by Plant-Derived Compounds

• Focus: Investigating plant-derived compounds that can target cancer cell metabolism and cell cycle, offering alternative treatment strategies for cancer.
• Potential Impact: Development of natural therapeutics that can complement or provide alternatives to conventional cancer treatments, with a focus on reducing side effects.

9. Differentiation Potential of Mesenchymal Stem Cells into Pancreatic β-Cells

• Focus: Exploring the potential for mesenchymal stem cells to differentiate into insulin-producing pancreatic β-cells, a potential treatment for diabetes.
• Potential Impact: Providing a source of β-cells for diabetes treatment, particularly for type 1 diabetes, where the body’s own insulin-producing cells are destroyed.

10. Zooming in Across the Skin: A Macro-to-Molecular Panorama

• Focus: Examining the skin at multiple levels, from tissue to cellular and molecular structures, to understand skin biology and potential therapeutic targets.
• Potential Impact: Advancing treatments for skin conditions, wound healing, and developing novel therapies for skin diseases.

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