Chemical warfare agents biomedical and psychological effects medical countermeasures and emergency response Third Edition by Brian J Lukey, James A Romano, Harry Salem ISBN 1498769217 9781498769211

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Product details:

ISBN 10: 1498769217

ISBN 13: 9781498769211 

Author:  Brian J. Lukey, James A. Romano, Harry Salem 

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11, 2001. The second edition titled, Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, included new epidemiological and clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment.

Since the second edition, the chemical warfare agent community has worked hard to advance research for protection and treatment and develop/improve response approaches for individuals and definitive care. Consequently, in addition to updating previous chapters, Chemical Warfare Agents: Biomedical and Psychological Effects, Medical Countermeasures, and Emergency Response, Third Edition features several new chapters that address the Syrian War, chemical destruction, the Organisation for the Prohibition of Chemical Weapons, biomarkers for chemical warfare agent exposure, field sensors, aircraft decontamination, lung/human on a chip, chemical warfare response decision making, and other research advancements.

Features:

• Describes the newest medical interventions, and the latest technologies deployed in the field, as well as developments in the international response to CW usage highlighting recent events in the Middle East
• Discusses the latest in organizational/interagency partitioning in terms of responsibilities for emergency response, not just in the United States but at the international level—whether prevention, mitigation, medical care, reclamation, or medico-legal aspects of such response
• Contains the most current research from bench-level experts

The third edition contains the most up-to-date and comprehensive coverage of the question of chemical warfare agent employment on the battlefield or in terrorism. Edited by workers that have been in the field for 35+ years, it remains faithful to the scientific “constants,” while evaluating and crediting the advances by the industry that have made us safer.

Table of contents:

Section I: General

1. Brief History and Use of Chemical Warfare Agents in Warfare and Terrorism
2. Chemistries of Chemical Warfare Agents
3. Toxicokinetics of Nerve Agents
4. Organization for the Prohibition of Chemical Weapons (OPCW): History, Mission, and Accomplishments
5. Chemical Holdings and Their Internationally Verified Destruction
6. Syria’s Chemical Disposal Program
7. The Use of Chemical Warfare Agents during the Syrian Civil War
8. U.S. CBRN Homeland Response and Civil Support

Section II: Agent Effects
9. Mustard Vesicants
10. Health and Psychological Effects of Low-Level Exposure to Chemical Warfare Nerve Agents
11. Inhalation Toxicology of Chemical Agents
12. Cyanides: Toxicology, Clinical Presentation, and Medical Management
13. The Structural Biology, Biochemistry, Toxicology, and Military Use of the Ricin Toxin and the Associated Treatments and Medical Countermeasures for Ricin Exposure
14. Medical Countermeasures for Intoxication by Botulinum Neurotoxin
15. Incapacitating Agents and Technologies: A Review
16. Screening Smokes: Applications, Toxicology, Clinical Considerations, and Medical Management

Section III: Protection
17. Personal Protective Equipment (PPE): Practical and Theoretical Considerations
18. Pyridostigmine Protection from Nerve Agent Intoxication: Concept to FDA Approval
19. Hormesis: Using Preconditioning to Build Biological Shields – A Novel Approach for Enhancing Resilience to Toxic Agents, Traumatic Illness/Injury, and Age-Related Degenerative Diseases

Section IV: Detection
20. Clinical Detection of Exposure to Chemical Warfare Agents
21. Biomarkers for Organophosphate Poisoning: Physiological and Pathological Responses
22. Field Sensors: Military and Civilian
23. Application of Genomic, Proteomic, and Metabolomic Technologies to the Development of Countermeasures against Chemical Warfare Agents
24. Nanomaterial-Based Sensors: Applications in Chemical Warfare Agent Detection and Identification

Section V: Decontamination
25. Chemical Warfare Agent Decontamination from Skin
26. Aircraft Decontamination and Mitigation

Section VI: Treatment
27. Military Chemical Casualty Treatment
28. Pre-Hospital and Hospital Response to Toxicological Mass Casualty Events: The Israeli Approach
29. An Overview of the NIAID/NIH Chemical Medical Countermeasures Product Research and Development Program
30. Medical Management of Chemical Warfare Agents
31. Protein-Based Bioscavengers of Organophosphorus Nerve Agents
32. Oxime Research
33. Brain-Penetrating Reactivators of Organophosphate-Inhibited Acetylcholinesterase
34. Nerve Agent-Induced Seizures and Status Epilepticus: Neuroprotective Strategies

Section VII: Predictive Modeling
35. Computational Modeling to Predict Human Toxicity
36. Lung-on-a-Chip
37. Body-on-a-Chip for Pharmacology and Toxicology
38. Animal Models
39. Real-Time Physiological Data Collection and Analysis in Animal Inhalation Models: Predictive and Diagnostic Implications
40. Contextual Factors Influencing Leadership Decision Making

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Tags: Brian J Lukey, James A Romano, Harry Salem, Chemical Warfare Agents, Biomedical Effects, Psychological Effects, Medical Countermeasures, Emergency Response