Chromatin Regulation of Early Embryonic Lineage Specification 1st Edition Jason Knott 331963187X 9783319631875

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Product details:

• ISBN 10: 331963187X
• ISBN 13: 9783319631875
• Author: Jason Knott

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

Table of contents:

1. Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development
2. Introduction
3. Events Associated with the First Lineage Decision: TE Versus ICM
4. The Second Lineage Decision: Epiblast Versus PrE
5. The Role of Chromatin Modifiers in the Formation of the Early Embryonic Lineages
6. CHD4: A Precise Subtle Regulator of Fate
7. BRG1/BAF Chromatin Remodellers
8. INO80 and ISWI Chromatin Remodellers
9. Concluding Remarks
10. References
11. CHD1 Controls Cell Lineage Specification Through Zygotic Genome Activation
12. Introduction
13. Mouse Preimplantation Development
14. CHD1 (Chromodomain Helicase DNA-Binding Protein 1) (Fig. 1)
15. Cell Lineage Specification
16. The Roles of CHD1 During Mouse Preimplantation Development
17. The Relationship Between CHD1 and HMGPI During Mouse Preimplantation Development
18. Conclusion and Future Directions
19. References
20. Transcriptional Regulation and Genes Involved in First Lineage Specification During Preimplantation
21. Mammalian Preimplantation Development
22. Maternal-to-Zygotic Transition
23. Embryo Compaction and Polarization
24. Blastomere Allocation and ICM/TE Separation
25. Key Transcriptional Regulation During ICM/TE Separation
26. Hippo Signaling and TE Specific Genes
27. Hippo Signaling Promotes ICM Fate Acquisition
28. Notch Signaling and TE Specific Genes
29. Transcription Factor AP-2γ (Tfap2c) Promotes TE
30. Heterogeneities in Early Blastomere Bias Cell Fate
31. Epigenetic Control on Transcription During Lineage Specification
32. Identification of Genes Essential for Lineage Specification
33. Conclusions
34. References
35. ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Pol
36. Introduction
37. Regulation of Lineage-Specific Gene Expressions by HIPPO Signaling and Cell Position
38. Apicobasal Cell Polarity Connects Cell Position to HIPPO Signaling
39. RHO and ROCK in Cell Lineage Specification
40. Activities of RHO and ROCK Are Essential for TE Formation
41. Statins Cause Phenotypes Similar to Inhibition of RHO and ROCK
42. Effect of RHO/ROCK Inhibition on Apicobasal Cell Polarity
43. Possible Mechanisms of How RHO and ROCK Regulate TE Specification
44. Questions to Be Answered
45. Concluding Remarks
46. References
47. XEN and the Art of Stem Cell Maintenance: Molecular Mechanisms Maintaining Cell Fate and Self-Renewa
48. Stem Cell, Defined
49. What Are the Extraembryonic Tissues?
50. Stem Cell Lines from the Extraembryonic Endoderm
51. Maintaining the XEN Cell State
52. Extrinsic Cues Maintaining the XEN Cell State
53. Intrinsic Cues Maintaining the XEN Cell State

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