Clinical Trial Optimization Using R 1st Edition Alex Dmitrienko 1351647156 9781351647151

This completed downloadable of Clinical Trial Optimization Using R 1st Edition Alex Dmitrienko

Instant downloaded Clinical Trial Optimization Using R 1st Edition Alex Dmitrienko pdf docx epub after payment.

Product details:

• ISBN 10: 1351647156
• ISBN 13: 9781351647151
• Author: Alex Dmitrienko

Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as supportive R tools, to evaluate and select among simultaneous competing designs or analysis options. It is applicable broadly to statisticians and other quantitative clinical trialists, who have an interest in optimizing clinical trials, clinical trial programs, or associated analytics and decision making. This book presents in depth the Clinical Scenario Evaluation (CSE) framework, and discusses optimization strategies, including the quantitative assessment of tradeoffs. A variety of common development challenges are evaluated as case studies, and used to show how this framework both simplifies and optimizes strategy selection. Specific settings include optimizing adaptive designs, multiplicity and subgroup analysis strategies, and overall development decision-making criteria around Go/No-Go. After this book, the reader will be equipped to extend the CSE framework to their particular development challenges as well.

Table of contents:

1 Clinical Scenario Evaluation and Clinical Trial Optimization

2 Clinical Trials with Multiple Objectives

3 Subgroup Analysis in Clinical Trials

4 Decision Making in Clinical Development

People also search:

clinical trial optimization

clinical trial simulation using r

a clinical trial is

a clinical trial is an observational study design

optimise clinical trial