Conquering RAS From Biology to Cancer Therapy 1st Edition by Asfar Azmi ISBN 0128035056 9780128035054

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Product details:

ISBN 10:      0128035056
ISBN 13: 978-0128035054
Author:      Asfar Azmi

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene.

The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS.

• Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities
• Showcases recent advancements in RAS research under one comprehensive volume
• Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

Conquering RAS From Biology to Cancer Therapy 1st Table of contents:

 

Section 1: RAS Cancer Biology

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Chapter 1: Ras and RASSF Effector Proteins

• Introduction
• Ras and RASSF1
• Ras and RASSF5 (NORE1)
• Ras and RASSF2
• Ras and RASSF3
• Ras and RASSF4 (AD037)
• Ras and RASSF6
• Effects of RASSF Proteins on Mitogenic Ras Effectors
• Therapeutic Ramifications
• Conclusion
• Glossary
• List of Acronyms and Abbreviations

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Chapter 2: Ras and the Hippo Pathway in Cancer

• Introduction
• The Hippo Tumor Suppressor Pathway
• MST and LATS as Central Mammalian Kinases in Hippo Signaling
• YAP Signaling and Its Regulation by Hippo
• Conclusions and Future Directions

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Chapter 3: The Many Roles of Ral GTPases in Ras-Driven Cancer

• Introduction
• Ral Regulation
• Ral Effectors
• Ral in Model Systems
• Ral in Tumorigenesis
• Inhibition of Ral
• Conclusions and Future Directions

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Chapter 4: Ras Pathway–Positive Childhood Acute Lymphoblastic Leukemia

• Introduction
• Childhood ALL
• Ras Pathway Activation
• Ras Pathway Mutations: Initiating or Secondary Event?
• Disease Evolution
• Prognostic Significance
• Targeted Therapies
• Conclusions
• List of Acronyms and Abbreviations

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Chapter 5: Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer

• Introduction
• Oncogenic Kras and Pancreatic Cancer Development
• Inflammation in PDAC Development
• Interrelationship Between Oncogenic Kras and Inflammation
• Obesity-Related Inflammation and Pancreatic Cancer
• Potential Targets for Intervention
• Conclusion
• List of Acronyms and Abbreviations

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Chapter 6: Activation of Ras by Post-Translational Modifications

• Introduction
• Ras Effectors
• Post-translational Modifications of Ras
• Conclusions
• List of Acronyms and Abbreviations

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Chapter 7: Cross Talk Between Snail and Mutant K-Ras in Pancreatic Cancer

• Introduction
• K-ras and Pancreatic Cancer Progression
• Epithelial-to-Mesenchymal Transition and Cancer Progression
• K-ras and Snail in Pancreatic Fibrosis and Inflammation
• Role of K-ras and Snail in Pancreatic Cancer Stem Cells
• Conclusion

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Section 2: Novel Therapeutic Approaches Targeting RAS and Related Pathways

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Chapter 8: Search for Inhibitors of Ras-Driven Cancers

• Background
• Directly Targeting Ras
• Indirectly Targeting Ras
• Phenotypic Screening for Targets and Inhibitors
• Conclusions
• List of Acronyms and Abbreviations

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Chapter 9: GTP-Competitive Inhibitors of RAS Family Members

• Introduction
• Targeting the RAS Active Site
• History of Covalent Inhibitors
• Simulations of GTP-Competitive RAS Inhibitors
• Covalently Targeting the KRAS Active Site
• Limitations of SML-Class Compounds
• Cysteine Targeting of the RAS Superfamily
• Conclusion

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Chapter 10: Next-Generation Strategies to Target RAF

• Introduction
• RAF Mutations and Oncogenesis
• RAF Inhibitors: Revisiting Lessons
• Targeting RAF in RAS Mutant Tumors
• Summary

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Chapter 11: Targeting Metabolic Vulnerabilities in RAS-Mutant Cells

• Introduction
• Cancer Metabolism Overview
• Metabolism in RAS-Mutant Cells
• Therapeutic Approaches to Target Metabolism
• Conclusion
• Glossary
• List of Acronyms and Abbreviations

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Chapter 12: Blocking SIAH Proteolysis to Control K-RAS-Driven Metastatic Cancer

• Introduction
• List of Acronyms and Abbreviations

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Chapter 13: Extracellular Signal-Regulated Kinase (ERK1 and ERK2) Inhibitors

• Introduction
• RAS Inhibitors
• RAF Inhibitors
• MEK Inhibitors
• Direct Small Molecule Inhibitors of ERK
• Conclusions and Future Directions

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Chapter 14: Targeting Rho, Rac, CDC42 GTPase Effector P21 Activated Kinases in K-Ras-Driven Cancer

• Introduction
• Ras Superfamily
• Rho Family GTPases and Cancer
• Rho GTPase Effectors
• P21 Activated Kinases (PAKs) in Cancer
• Group I PAKs and Cancer
• Group II PAKs in Cancer
• PAK4 in Pancreatic Cancer Stemness and Drug Resistance
• Small Molecule Inhibitors Targeting PAKs
• Allosteric PAK Modulators
• Conclusions and Future Directions
• List of Acronyms and Abbreviations

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