Drug Delivery Trends Volume 3 Expectations and Realities of Multifunctional Drug Delivery Systems 1st edition by Ranjita Shegokar 9780128178706 0128178701

Chapter 1. Bioactive hybrid nanowires: a new in trend for site-specific drug delivery and targeting

1. Introduction

2. Types of nanowires

3. Production methods

4. Applications of nanowires

5. Conclusions

Chapter 2. Opportunities and challenges of 3D-printed pharmaceutical dosage forms

1. Introduction

2. Materials

3. Technology details

4. Regulatory and quality considerations

5. Pharmaceutical applications for drug delivery

6. Conclusions

Chapter 3. Marketing authorization and licensing of medicinal products in EU: Regulatory aspects

1. Introduction

2. European Union legal framework, hierarchy, and committees

3. Legal framework for licensing medicines for human use in the EU

4. Conclusion

Chapter 4. Clinical considerations on micro- and nanodrug delivery systems

1. Introduction

2. Outline of drug development

3. Micro- and nanoparticles in drug delivery

4. Applications of micro- and nanoparticles

5. Regulatory aspects of nanotechnology-based products

6. Conclusion

Chapter 5. Nanoparticulate treatments for oral delivery

1. Introduction

2. Need for nanotechnology in oral solid dosage forms

3. Formulation perspectives

4. Challenges

5. Conclusions

Abbreviations

Chapter 6. Pharmaceutical mini-tablets: a revived trend

1. Introduction

2. Advantages of mini-tablets

3. Manufacturing

4. Types of mini-tablets

5. Methods of manufacturing mini-tablets

6. Challenges in the manufacturing of mini-tablets

7. Coating of mini-tablets

8. Fluidized-bed coating of mini-tablets

9. Pan coating of mini-tablets

10. Novel coating technology for mini-tablets

11. Packaging of mini-tablets

12. Encapsulation of mini-tablets into capsules

13. Unit-dose packing of mini-tablets into sachets

14. Conclusion

Chapter 7. Liquid crystalline drug delivery systems

1. Introduction

2. Preparation of LC systems

3. Characterization of liquid crystalline phases

4. Applications of liquid crystalline systems

5. Conclusion

Chapter 8. Amorphous drug stabilization using mesoporous materials

1. Background

2. Introduction

3. Mesoporous materials

4. Structural characterization of mesoporous materials

5. Mesoporous materials in drug delivery

6. Different forms of the loaded drug: monolayer versus pore filling

7. Drug loading techniques

8. Performance of drug-loaded mesoporous materials

9. Conclusion

Chapter 9. “Quality” of pharmaceutical products for human use—underlying concepts and required practices

1. Introduction

2. In vivo testing (clinical studies)

3. In vitro assessments or drug dissolution testing

4. Linking in vitro dissolution results to in vivo characteristics/IVIVC

5. Regulatory standards and requirements

6. Limitations and deficiencies of the current practices and requirements for quality assessment

7. Future outlook

8. Conclusions

Chapter 10. Optimizing intraperitoneal drug delivery: pressurized intraperitoneal aerosol chemotherapy (PIPAC)

1. Introduction

2. Optimizing drug therapy in peritoneal metastasis

3. Limitations of intraperitoneal chemotherapy

4. Understanding drug uptake into peritoneal nodes

5. Pharmacokinetics aspects of intraperitoneal chemotherapy

6. Pharmacodynamic aspects in intraperitoneal chemotherapy

7. Pharmacological interventions to increase drug uptake

8. Role of formulation

9. Physical interventions to improve drug uptake

10. Specifications for an ideal intraperitoneal drug delivery system

11. Peritoneal aerosol medicine

12. Pressurized intraperitoneal aerosol chemotherapy

13. Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy

14. Chemotherapeutic agents used as PIPAC

15. Preclinical studies

16. Combination of PIPAC with systemic chemotherapy

17. In silico modeling

18. Conclusion and outlook

Chapter 11. Upscaling and GMP production of pharmaceutical drug delivery systems

1. Scalability

2. Sustainability

3. GMP compliance

4. Conclusion