Drug Selectivity An Evolving Concept in Medicinal Chemistry 1st Edition by Norbert Handler, Helmut Buschmann, Raimund Mannhold, Jörg Holenz 3527674381 9783527674381

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ISBN-10 :  3527674381 

ISBN-13 :  9783527674381 

Author:  Norbert Handler, Helmut Buschmann, Raimund Mannhold, Jörg Holenz

The book “Drug Selectivity – An Evolving Concept in Medicinal Chemistry” provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process.
The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

Drug Selectivity An Evolving Concept in Medicinal Chemistry 1st Table of contents:

Part I : Introduction
CHAPTER 1
Polypharmacology in Drug Discovery (Pages: 1-29)
Oscar Méndez-Lucio,  J. Jesús Naveja,  Hugo Vite-Caritino,  Fernando D. Prieto-Martínez,  José L. Medina-Franco
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Part II : Selectivity of Marketed Drugs
CHAPTER 2
Kinase Inhibitors (Pages: 31-53)
Peng Wu,  Michael Givskov,  Thomas E. Nielsen
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CHAPTER 3
Repositioning of Drug – New Indications for Marketed Drugs (Pages: 55-78)
Ren Kong,  Stephen T. Wong
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CHAPTER 4
Discovery Technologies for Drug Repurposing (Pages: 79-100)
Naiem T. Issa,  Stephen W. Byers,  Sivanesan Dakshanamurthy
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Part III : Unselective Drugs in Drug Discovery
CHAPTER 5
Personalized Medicine (Pages: 101-133)
Christian Noe,  Volker Baumann
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CHAPTER 6
Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases (Pages: 135-159)
Annachiara Gandini,  Federica Prati,  Elisa Uliassi,  Maria L. Bolognesi
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CHAPTER 7
Designing Approaches to Multitarget Drugs (Pages: 161-205)
Luca Costantino,  Daniela Barlocco
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CHAPTER 8
The Linker Approach: Drug Conjugates (Pages: 207-245)
Daniel Merk,  Manfred Schubert-Zsilavecz
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CHAPTER 9
Merged Multiple Ligands (Pages: 247-274)
Hongming Chen,  Udo Bauer,  Ola Engkvist
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CHAPTER 10
Pharmacophore Generation for Multiple Ligands (Pages: 275-312)
Norbert Handler
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CHAPTER 11
Cellular Assays (Pages: 313-333)
Ye Fang
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Part IV : Therapeutic Areas for Designed Multiple Ligands
CHAPTER 12
Developing Serotonergic Antidepressants Acting on More Than the Serotonin Transporter (Pages: 335-367)
Gerard J. Marek
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CHAPTER 13
Multiple Ligands Targeting the Angiotensin System for Hypertension (Pages: 369-395)
Agustin Casimiro-Garcia
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CHAPTER 14
Multiple Peroxisome Proliferator-Activated Receptor-Based Ligands (Pages: 397-432)
Dmytro Kukhtar,  Miquel Mulero,  Raul Beltrán-Debón,  Cristina Valls,  Gerard Pujadas,  Santiago Garcia-Vallve
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CHAPTER 15
Antibiotics (Pages: 433-475)
Jean-Philippe Surivet,  Philippe Panchaud
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CHAPTER 16
Multiple Ligands in Neurodegenerative Diseases (Pages: 477-508)

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Tags: Drug Selectivity, Evolving Concept, Medicinal Chemistry, Norbert Handler, Helmut Buschmann, Raimund Mannhold, Jörg Holenz