E cole de Physique des Houches Session CII 7 July 1 August 2014 From molecules to living organisms an interplay between biology and physics 1st Edition Cugliandolo 0191067253 9780191067259

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Product details:

• ISBN 10: 0191067253
• ISBN 13: 9780191067259
• Author: Cugliandolo

The book gathers lecture notes of courses given at the 2014 summer school on integrated biology in Les Houches, France, Session CII. It addresses an emerging field ranging from molecules to cells and to organisms. Through examples it presents a new way of thinking using a combination of interdisciplinary and cutting-edge methods, bridging physics and biology beyond current biophysics. Important novel developments are expected in the coming years that may well introduce paradigm shifts in biological science. The school had the ambition to prepare participants to become major actors in these breakthroughs. The power of integrated approaches is illustrated through two cases: interactions between viruses and host cells, and flower development. The role of forces in biology, as well as their mathematical modeling, is illustrated in both processes: how they allow flower organs to emerge or how they control membrane fusion during virus budding. The book also underlines the importance of conformational changes and dynamics of proteins particularly during membrane processes. It explains how membrane proteins can be handled and studied by molecular simulations. Finally, the book also contains concepts in cell biology, in thermodynamics and several novel approaches such as in-cell NMR.

Table of contents:

Part 1 Concepts in cell biology and examples of multiscale studies in biology

1 Introduction to cell biology

2 A small leak will sink a great ship: HIV–host interactions

Nikolas Herold, Hans-Georg Kräusslich, and Barbara Müller

5 NMR spectroscopy: from basic concepts to advanced methods

6 Size exclusion chromatography with multi-angle laser light scattering (SEC-MALLS) to determine pro

Albert Guskov and Dirk Jan Slotboom

7 Mechanisms controlling time measurement in plants and their significance in natural populations

George Coupland

8 Forces in plant development

9 An introduction to modeling the initiation of the floral primordium

Christophe Godin, Eugenio Azpeitia, and Etienne Farcot

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