Essential Chemistry for Formulators of Semisolid and Liquid Dosages 1st Edition by Vitthal Kulkarni Phd, Charles Shaw 0128010242 9780128010242

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ISBN-10 :  0128010242 

ISBN-13 :  9780128010242

Author:   Vitthal S. Kulkarni Phd, Charles Shaw 

A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations.

Essential Chemistry for Formulators of Semisolid and Liquid Dosages 1st Table of contents:

Chapter 1. Introduction
Chapter 2. Surfactants, Lipids, and Surface Chemistry
2.1. Introduction
2.2. Types of Surfactants
2.3. Natural Surfactants
2.4. The Role of Surfactants in Pharmaceutical Formulations
2.5. Surface Chemistry for Pharmaceutical Formulations
2.6. Conclusion
Chapter 3. Drug Delivery Vehicles
3.1. Introduction
3.2. Emulsion Drug Delivery Systems
3.3. Liposome Drug Delivery Systems
3.4. Other Nanodrug Delivery Systems
3.5. Conclusion
Chapter 4. Formulating Creams, Gels, Lotions, and Suspensions
4.1. Introduction
4.2. Creams and Lotions
4.3. Gels, Ointments, and Suspensions
4.4. Formulating with Liposomes
4.5. Excipients
4.6. Conclusion
Chapter 5. Use of Polymers and Thickeners in Semisolid and Liquid Formulations
Background
5.1. Polymers as Styling Agents
5.2. Polymers as Conditioning Agents
5.3. Polymers as Preservatives
5.4. Polymers as Penetration Enhancers
5.5. Polymers as Thickening and Suspending Agents
5.6. Characteristics of Commonly Used Thickening, Gelling, and Suspending Agents
Chapter 6. Aerosols and Nasal Sprays
6.1. Aerosols
6.2. Nasal Sprays
Chapter 7. Preparation and Stability Testing
7.1. How Formulations Are Put Together
7.2. Mixing Systems
7.3. Quality by Design (QbD) for Formulation and Process Development
7.4. Stability Testing
Chapter 8. Particle Size Analysis: An Overview of Commonly Applied Methods for Drug Materials and Products
8.1. Introduction
8.2. Laser Diffraction
8.3. Particle Size Evaluation by Microscopy
8.4. Conclusion
Chapter 9. Rheological Studies
9.1. General Terms and Definitions
9.2. Instruments and Measuring Geometries
9.3. Material Behavior
9.4. Rheological Studies
9.5. Practical Application of Rheological Data
Chapter 10. Microscopy Techniques
10.1. Introduction
10.2. Optical Microscopy
10.3. Scanning Electron Microscopy
10.4. Transmission Electron Microscopy
10.5. Atomic Force Microscopy
10.6. Conclusion
Chapter 11. Miscellaneous Physical, Chemical, and Microbiological Test Methods
11.1. General Physical Tests
11.2. General Chemical Tests
11.3. General Microbiological Tests
11.4. Product-Specific Tests
Chapter 12. An Overview of Regulatory Aspects for Pharmaceutical Semisolid Dosages
12.1. Quality Data
12.2. Types of Regulatory Submissions
12.3. Resources—ICH
12.4. Resources—FDA
12.5. Resources—WHO

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