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Product details:
- ISBN 10: 1351778323
- ISBN 13: 9781351778329
- Author: Surinder K. Batra
Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Table of contents:
1. Programmed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer
2. Nuclear Factor Kappa-B: Bridging Inflammation and Cancer
3. The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma
4. Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting in Cancer
5. Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection
6. Targeting Subgroup-specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma
7. Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas
8. Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers
9. Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications
10. Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy
11. Therapeutic Options for Prostate Cancer: A Contemporary Update
12. Regulation and Targeting of MUCINS in Pancreatic Cancer
13. Targeted Therapy for Cancer Stem Cells
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