Gold I III Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins Raphael Enoque Ferraz De Paiva 3030008533 9783030008536

Gold I III Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins 1st edition by Raphael Enoque Ferraz De Paiva – Ebook Instant Download/Delivery ISBN(s): 3030008533, 9783030008536

Product details:

• ISBN 10: 3030008533
• ISBN 13: 9783030008536
• Author: Raphael

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Table of contents:

Part I. Au(I) Complexes

1. Au(I)-Phosphine Series Design

2. Probing the Protein: Ion Mobility Spectrometry

3. Probing Gold: X-Ray Absorption Spectroscopy

4. Probing Cells: Evaluating Cytotoxicity

Part II. Au(III) Complexes

5. Au(III) Series with κ2C,N and κ2N,N′ Ligands

6. “Dual-Probe” X-Ray Absorption Spectroscopy

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