Handbook of In Vivo Chemistry in Mice: From Lab to Living System 1st Edition Katsunori Tanaka 3527344322 9783527344321

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Product details:

• ISBN-10 ‏ : ‎ 3527344322
• ISBN-13 ‏ : ‎ 9783527344321
• Author: Katsunori Tanaka

This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs.

The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals.

Table of contents:

1 Summary of Currently Available Mouse Models 1 Ami Ito, Namiko Ito, Kimie Niimi, Takashi Arai, and Eiki Takahashi

2 General Notes of Chemical Administration to Live Animals 33 Ami Ito, Namiko Ito, Takashi Arai, Eiki Takahashi, and Kimie Niimi

3 Optical-Based Detection in Live Animals 55 Mikako Ogawa and Hideo Takakura

4 Ultrasound Imaging in Live Animals 103 Francesco Faita

5 Positron Emission Tomography (PET) Imaging in Live Animals 127 Xiaowei Ma and Zhen Cheng

6 Single-Photon Emission Computed Tomographic Imaging in Live Animals 151 Yusuke Yagi, Hidekazu Kawashima, Kenji Arimitsu, Koki Hasegawa, and Hiroyuki Kimura

7 Radiotherapeutic Applications 185 Koki Hasegawa, Hidekazu Kawashima, Yusuke Yagi, and Hiroyuki Kimura

8 Metabolic Glycan Engineering in Live Animals: Using Bio-orthogonal Chemistry to Alter Cell Surface Glycans Danielle H. Dube and Daniel A. Williams

9 In Vivo Bioconjugation Using Bio-orthogonal Chemistry 249 Maksim Royzen, Nathan Yee, and Jose M. Mejia Oneto

10 In Vivo Targeting of Endogenous Proteins with Reactive Small Molecules 281 Naoya Shindo and Akio Ojida

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