Human Drug Metabolism Third Edition Michael D. Coleman

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Product details:

• ISBN-10 ‏ : ‎ 1119458560
• ISBN-13 ‏ : ‎ 978-1119458562
• Author: Michael D. Coleman

The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.

Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s.

Table of contents:

1 Introduction

2 Drug Biotransformational Systems – Origins and Aims

3 How Oxidative Systems Metabolise Substrates

4 Induction of Cytochrome P450 Systems

5 Cytochrome P450 Inhibition

6 Conjugation and Transport Processes

7 Factors Affecting Drug Metabolism

8 Role of Metabolism in Drug Toxicity

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