Human Monoclonal Antibodies Methods and Protocols 2nd Edition by Michael Steinitz ISBN 9781493989577 149398957X

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Product details:

ISBN 10: 149398957X

ISBN 13: 9781493989577

Author: Michael Steinitz 

The introduction of monoclonal antibodies revolutionized immunology. The development of human monoclonal antibodies was inspired primarily by the enormous clinical benefits promised by these reagents which can be used as anti-inflammatory reagents, anti-tumor reagents and reagents for passive immunization in a variety of pathologies. Human Monoclonal Antibodies: Methods and Protocols presents technical protocols of cellular and molecular methods for the production, purification and application of human monoclonal antibodies, as well as review articles on related topics of human monoclonal and polyclonal antibodies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Human Monoclonal Antibodies: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies which will prove invaluable in a clinical setting.

Table of contents: 

1. Human Monoclonal Antibodies: The Residual Challenge of Antibody Immunogenicity

2. Technical and Ethical Limitations in Making Human Monoclonal Antibodies (An Overview)

3. Therapeutic Human Monoclonal Antibodies in Inflammatory Diseases

4. Therapeutic Human Monoclonal Antibodies Against Cancer

5. Polyclonal and Monoclonal Antibodies in Clinic

6. Production of Human Monoclonal Antibodies by the Epstein–Barr Virus Method

7. Humanization and Simultaneous Optimization of Monoclonal Antibody

8. Chimeric Antibodies

9. Recombinant Genetic Libraries and Human Monoclonal Antibodies

10. Production of Stabilized scFv Antibody Fragments in the E. coli Bacterial Cytoplasm

11. Construction and Production of an IgG-Like Tetravalent Bispecific Antibody, IgG–Single-Chain Fv Fusion

12. Construction of Human Antibody Gene Libraries and Selection of Antibodies by Phage Display

13. Antigen-Specific Human Monoclonal Antibodies from Transgenic Mice

14. Phage Display Technology for Human Monoclonal Antibodies

15. Antigen-Specific In Vitro Immunization: A Source for Human Monoclonal Antibodies

16. Methods for Radiolabelling of Monoclonal Antibodies

17. Purification of Human Monoclonal Antibodies and Their Fragments

18. Idiotype-Specific Intravenous Immunoglobulin (IVIG) for Therapy of Autoimmune Diseases

19. Correction to: Therapeutic Human Monoclonal Antibodies Against Cancer

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Tags: Michael Steinitz, Human Monoclonal Antibodies, Methods, Protocols