Inhalation aerosols physical and biological basis for therapy 3rd Edition by Anthony Hickey, Heidi Mansour ISBN 1351660519 9781351660518

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ISBN 10:    1351660519
ISBN 13: 978-1351660518
Author:      Anthony Hickey, Heidi Mansour

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years.

In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies.

The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Inhalation aerosols: physical and biological basis for therapy 3rd Table of contents:

PART I FUNDAMENTALS

1 Physicochemical properties of respiratory particles and formulations

2 Particle deposition in the respiratory tract and the effect of respiratory disease

3 Mathematical modeling of inhaled therapeutic aerosol deposition in the respiratory tract

4 Lung transporters and absorption mechanisms in the lungs

5 Bioavailability of inhaled compounds

6 3D models as tools for inhaled drug development

7 Overview of the delivery technologies for inhalation aerosols

PART II APPLICATIONS, INFLUENCE OF LUNG DISEASE PATHOPHYSIOLOGY ON AEROSOL DEPOSITION, INHALER DEVICE TECHNIQUE IN RESPIRATORY DISEASE, AND CLINICAL OUTCOMES IN DRUG PERFORMANCE ASSESSMENT

8 Neonatal and pediatric inhalation drug delivery

9 Asthma

10 Drug delivery in pulmonary aspergillosis

11 Lung cancer inhalation therapeutics

12 Inhaled therapeutics in chronic obstructive pulmonary disease

13 Cystic fibrosis infection and biofilm busters

14 Current and future CFTR therapeutics

15 Innate and adaptive barrier properties of airway mucus

16 Nontuberculous mycobacteria

17 Inhalational therapies for non-cystic fibrosis bronchiectasis

18 Pulmonary fibrosis

19 Therapeutics in pulmonary hypertension

20 Overview of lung surfactant and respiratory distress syndrome

21 Surfactant aerosol therapy for nRDS and ARDS

22 Fundamentals in nasal drug delivery

23 Inhaled therapeutics against TB: The promise of pulmonary treatment and prevention strategies in the clinic

PART III INTEGRATED STRATEGIES (REFLECTING COMBINED ELEMENTS FROM CHAPTERS 8 THROUGH 23)

24 Inhaled medication: Factors that affect lung deposition

25 A critical perspective on future developments based on the knowledge we have now

26 Ensuring effectiveness and reproducibility of inhaled drug treatment

27 Conclusion

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