Integration of Omics Approaches and Systems Biology for Clinical Applications 1st Edition Antonia Vlahou 9781119181149,1119181143

Integration of Omics Approaches and Systems Biology for Clinical Applications 1st Edition Antonia Vlahou – Ebook Instant Download/Delivery ISBN(s): 9781119181149,1119181143

Product details:

• ISBN-10 ‏ : ‎ 1119181143
• ISBN-13 ‏ : ‎ 978-1119181149
• Author: Vlahou

This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed.

Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting.

Table of contents:

Part I: Platforms for Molecular Data Acquisition and Analysis

Part II: Progressing Towards Systems Medicine

Part III: Test Cases CKD and Bladder Carcinoma

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