International Review of Cell and Molecular Biology Volume 330 1st Edition by Lorenzo Galluzzi ISBN 9780128124673 0128124679

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Product details:

ISBN 10:  0128124679

ISBN 13: 9780128124673

Author: Lorenzo Galluzzi

Secreted chiefly from the underlying mesoderm, the morphogen retinoic acid (RA) iswell known to contribute to the specification, patterning, and differentiation of neuralprogenitors in the developing vertebrate nervous system. Furthermore, RA influencesthe subtype identity and neurotransmitter phenotype of subsets of maturing neurons,although relatively little is known about how these functions are mediated. This reviewprovides a comprehensive overview of the roles played by RA signaling during theformation of the central and peripheral nervous systems of vertebrates and high-lights its effects on the differentiation of several neurotransmitter systems. In addi-tion, the evolutionary history of the RA signaling system is discussed, revealingboth conserved properties and alternate modes of RA action. It is proposed that com-parative approaches should be employed systematically to expand our knowledgeof the context-dependent cellular mechanisms controlled by the multifunctionalsignaling molecule RA.

Table of contents: 

1. Introduction

2. Developmental Signaling

3. Retinoids as Morphogens, Teratogens, and Drugs

4. RA Signaling Pathway

5. Major Functions of RA Signaling

6. RA Signaling During Nervous System Development

7. RA Signaling and the Establishment of Neurotransmitter Systems

8. RA Signaling Outside Vertebrates: Evolutionary Considerations

9. Concluding Remarks

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Tags: Lorenzo Galluzzi, International Review, Cell, Molecular Biology