Ion Channels as Therapeutic Targets Part B 1st edition by Donev, Rossen 9780128052426 0128052422

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• ISBN 10:0128052422 

• ISBN 13:9780128052426

• Author:Donev, Rossen 

Ion Channels as Therapeutic Targets, Part B
This volume is the second part of the thematic on Ion Channels as Therapeutic Targets.

The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists,  brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Provides cutting-edge developments in protein chemistry and structural biology
Discusses the use of ion channels as therapeutic targets
Chapters are written by authorities in their field
Targeted to a wide audience of researchers, specialists, and students

Ion Channels as Therapeutic Targets Part B 1st Table of contents:

 Chapter One: Role of Hemichannels in CNS Inflammation and the Inflammasome Pathway
Abstract
1 Introduction
2 Role of Connexin Hemichannels in the Inflammatory Cascade of the CNS
3 Connexin Hemichannels and Their Roles in Response to Injury and Inflammation
4 Conclusion
Chapter Two: P2X7 Receptor as a Therapeutic Target
Abstract
1 Introduction
2 P2X7 Receptor Ligands
3 Agonists and ATP-Competitive Antagonists
4 Agonists
5 Antagonists
6 Allosteric Modulators
7 P2X7 in Inflammation
8 P2X7 Receptor in Infectious Diseases
9 P2X7 Receptor in Osteoporosis
10 P2X7 Receptor in Rheumatoid Arthritis
11 P2X7 Receptor in Diabetes
12 P2X7 Receptor in Neurological Disorders
13 Multiple Sclerosis
14 Alzheimer’s Disease
15 Huntington’s Disease
16 Amyotrophic Lateral Sclerosis
17 Epilepsy
18 P2X7 Receptor in Mood Disorders
19 P2X7 Potential in Oncologic Treatment
20 Conclusions and Future Perspectives
Acknowledgments
Chapter Three: Polymodal Transient Receptor Potential Vanilloid Type 1 Nocisensor: Structure, Modulators, and Therapeutic Applications
Abstract
1 Introduction
2 Expression and Regulation of TRPV1 Channel
3 Structural Aspects of TRPV1 Channel
4 Modulators of TRPV1 Channel
5 Therapeutic Roles of TRPV1 and Its Modulators in Pain and Other Disorders
6 Conclusion
Acknowledgments
Chapter Four: TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer
Abstract
1 Introduction
2 Overview of TRPM8 Channels
3 Roles of TRPM8 Channels in Malignant Tumors
4 Expression of TRPM8 in Pancreatic Cancer
5 TRPM8 is Overexpressed in Pancreatic Cancer Cell Lines and Tissues
6 TRPM8 is Aberrantly Expressed in Premalignant and Malignant Pancreatic Tumors
7 Biological Roles of TRPM8 Channels in Pancreatic Cancer
8 TRPM8 is Required for Proliferation of Pancreatic Cancer Cells
9 Downregulation of TRPM8-Induced Replicative Senescence
10 TRPM8 is Required for Invasion in Pancreatic Cancer Cells
11 Mechanisms for the Biological Roles of TRPM8 Channels in Cancer
12 TRPM8 as a Cancer Biomarker and Therapeutic Target
13 Conclusion and Future Perspectives
Acknowledgments
Chapter Five: Ion Channels in the Eye: Involvement in Ocular Pathologies
Abstract
1 Introduction
2 The Ocular Surface
3 Lens
4 Aqueous Humor Inflow Pathway
5 Aqueous Humor Outflow Pathway
6 Retina
7 The Retinal Pigment Epithelium
Acknowledgments
Chapter Six: Calcium-Activated Potassium Channels: Potential Target for Cardiovascular Diseases
Abstract
1 Introduction
2 Big Conductance Ca2 +-Activated K+ Channel
3 Role of BKCa in Cardiovascular System
4 Perspective for BKCa Channels as Potential Target for Cardiovascular Diseases
5 Intermediate Conductance Ca2 +-Activated K+ Channel
6 Role of IKCa in Cardiovascular System
7 Perspective for IKCa Channels as Potential Target for Cardiovascular Diseases
8 Small Conductance Ca2 +-Activated K+ Channels
9 Role of SKCa in Cardiovascular System
10 Perspective for SKCa Channels as Potential Target for Cardiovascular Diseases
Acknowledgment
Chapter Seven: The Modulation of Potassium Channels in the Smooth Muscle as a Therapeutic Strategy for Disorders of the Gastrointestinal Tract
Abstract
1 Gut Motility and Functional Gastrointestinal Diseases
2 Gastrointestinal Smooth Muscle Contractility
3 Ion Channels
4 Concluding Remarks: Ideal Requirements of New Channel Modulators to be Considered Possible New Pharmacotherapeutic Options
Chapter Eight: Targeting the Channel Activity of Viroporins
Abstract
1 Introduction
2 The Influenza A Virus Matrix Protein 2 (IAV M2 or AM2)
3 The Hepatitis C Virus p7 Protein (HCV-p7)
4 The Coronavirus Envelope Protein (CoV E)
5 The Respiratory Syncytial Virus Small Hydrophobic Protein (RSV SH)
6 The Human Immunodeficiency Virus Viral Protein U (HIV-1-Vpu)
7 6K, Agnoprotein, and 2B
8 Host–Cell Responses Triggered by Viroporin Activity
9 Modulation of Protein–Protein Interactions Involving Viroporins
Acknowledgments
Chapter Nine: Contribution of Automated Technologies to Ion Channel Drug Discovery
Abstract
1 Introduction
2 Nonfunctional Assays
3 Functional Assays
4 Concluding Remarks
Acknowledgments
Author Index
Subject Index

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