Iron Sulfur Clusters in Chemistry and Biology Volume 1 1st edition by Tracy Rouault ISBN 3110478501 9783110478501

“Iron-Sulfur Clusters in Chemistry and Biology, Volume 1,” edited by Tracy Rouault, provides a comprehensive exploration of the chemistry, biochemistry, and biological significance of iron-sulfur (Fe-S) clusters. These clusters are essential components of many metalloenzymes and play a critical role in various biological processes, including electron transfer, enzyme catalysis, and gene regulation. Volume 1 of this series delves into the fundamental aspects of Fe-S clusters, from their chemical properties to their functional roles in cellular systems.

The book is divided into several sections that address the historical development of iron-sulfur chemistry, the structural and electronic properties of these clusters, and their importance in biochemistry and physiology. It also discusses the latest experimental techniques used to study Fe-S clusters, such as EPR and Mössbauer spectroscopy, and provides insight into the role of Fe-S clusters in specific enzymes, such as nitrogenase and biotin synthase.

Key topics covered include:

• The historical perspective of iron-sulfur proteins and their discovery.
• The chemistry and structural diversity of Fe-S clusters.
• The role of Fe-S clusters in metalloenzymes and their redox properties.
• The use of bioinorganic spectroscopy (EPR, Mössbauer) to study Fe-S proteins.
• The molecular mechanisms underlying the function and repair of Fe-S clusters in biological systems.
• The specific functions of Fe-S clusters in important biological processes like nitrogen fixation, electron transport, and sulfur metabolism.
• The interactions of Fe-S clusters with small molecules, such as nitric oxide and molecular oxygen.

This volume is aimed at researchers, graduate students, and professionals in the fields of bioinorganic chemistry, biochemistry, molecular biology, and related disciplines. It serves as both an introduction to the subject and a reference for those seeking an in-depth understanding of the role of iron-sulfur clusters in living organisms.