Irreversible Electroporation in Clinical Practice 1st Edition by Martijn Meijerink, Hester Scheffer, Govindarajan Narayanan ISBN 3319855719 9783319855714

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Product details:
ISBN 10: 3319855719
ISBN 13: 9783319855714
Author: Martijn Meijerink, Hester Scheffer, Govindarajan Narayanan

This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks.

Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitionersand trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.

Irreversible Electroporation in Clinical Practice 1st Edition Table of contents:

Chapter 1: Fundamentals of Irreversible Electroporation

• What is Irreversible Electroporation?
• Basic Principles of Electroporation
• Mechanism of Cell Death in IRE
• Overview of Electroporation Technologies

Chapter 2: Physics and Engineering of Electroporation

• Electrical Properties of Cells and Tissues
• Electrode Design and Electroporation Parameters
• Technological Advancements in IRE Equipment

Chapter 3: Clinical Indications for Irreversible Electroporation

• IRE in Oncology: Treating Solid Tumors
• IRE in Hepatic and Pancreatic Tumors
• Potential Applications in Other Medical Fields
• Patient Selection Criteria

Chapter 4: IRE Procedure: Technique and Protocols

• Preoperative Assessment and Planning
• Intraoperative Technique: Step-by-Step Guide
• Choosing Electrode Placement
• Managing IRE Equipment and Monitoring

Chapter 5: Postoperative Care and Follow-up

• Immediate Postoperative Care
• Monitoring for Complications
• Long-term Follow-up Strategies
• Assessing Treatment Efficacy and Outcomes

Chapter 6: IRE in Combination with Other Therapies

• IRE and Chemotherapy
• IRE and Radiotherapy
• Combining IRE with Immunotherapy
• Multimodal Treatment Approaches

Chapter 7: IRE for Non-oncological Applications

• IRE in Cardiology and Electrophysiology
• IRE in the Treatment of Infections
• Other Emerging Clinical Applications

Chapter 8: Challenges and Limitations of Irreversible Electroporation

• Limitations in Tumor Types and Sizes
• Complications and Side Effects
• Technological and Operational Challenges
• Clinical Trials and Research Gaps

Chapter 9: Future Directions of Irreversible Electroporation

• Innovations in Electroporation Technology
• Potential for Personalized IRE Treatments
• The Role of Artificial Intelligence in IRE
• Expanding the Scope of IRE Applications

Chapter 10: Ethical Considerations and Patient Counseling

• Ethical Implications of Electroporation-Based Therapies
• Informed Consent for IRE Procedures
• Discussing Risks and Benefits with Patients
• Psychological Support for IRE Patients

Appendices

• Glossary of Key Terms
• List of IRE Clinical Trials and Research Studies
• IRE Protocol Templates and Guidelines

Index

• Index of Key Terms, Treatments, and Procedures

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Martijn Meijerink,Hester Scheffer,Govindarajan Narayanan,Irreversible Electroporation,Clinical Practice