Kendig Disorders of the Respiratory Tract in Children 9th Edition by Robert Wilmott, Andrew Bush, Robin Deterding, Felix Ratjen, Peter Sly, Heather Zar, Albert Li ISBN 9780323555944 0323555942

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ISBN 10: 0323555942
ISBN 13: 9780323555944
Author: Robert Wilmott, Andrew Bush, Robin Deterding, Felix Ratjen, Peter Sly, Heather Zar, Albert Li

Kendig Disorders of the Respiratory Tract in Children 9th Edition Table of contents:

Section 1 General Basic and Clinical Considerations

1 The History and Physical Examination

The History

The Physical Examination

Common Signs and Symptoms of Chest Disease in Children

Conclusion

Suggested Reading

References

2 Molecular Determinants of Lung Morphogenesis

Introduction

Organogenesis of the Lung

Molecular Mechanisms Directing Lung Development

Development of the Pulmonary Host Defense Systems

Gene Mutations in Lung Development and Function

Summary

References

3 Basic Genetics and Epigenetics of Childhood Lung Disease

Types of Genetic Variation

Technologies to Identify Genetic Variation

Interpretation of Genetic Variation

When to Consider Clinical Genetic Testing

Research Study Designs to Attribute Genetic Variation to Disease

Epigenetics—Terminology and Technology

“Multi-Omics” Approaches to Refine Genotype-Phenotype Associations

Websites

References

4 Environmental Contributions to Respiratory Disease in Children

Vulnerability of Children to Adverse Environmental Exposures

Environmental Contributions to Acute Respiratory Illness and Pneumonia

Environmental Contributions to Asthma

Summary

References

5 The Surfactant System

Surfactant Composition and Metabolism

Surfactant Metabolism and Secretion

Alveolar Life Cycle of Surfactant

Surfactant Function

Pressure-Volume Curves

Host Defense Functions of Surfactant

Surfactant Deficiency

Surfactant Treatment of Surfactant Deficiency

References

6 The Structural and Physiologic Basis of Respiratory Disease

Normal Lung Anatomy and Cell Function

Airways

Alveolar Region

Pulmonary Vascular System

Lymphatic System

Innervation of the Lung

Interstitium

Growth and Development of the Lung

The Lung at Birth

Postnatal Lung Growth

Ventilation and Mechanics of Breathing

Definitions and Symbols

Elastic Recoil of the Lung

Compliance of the Lung

Elastic Properties of the Chest Wall

Lung Volumes

Regional Lung Volumes

Dynamic (Flow-Resistive) Properties of the Lung

Distribution of Ventilation

Pulmonary Circulation

Pulmonary Vascular Pressures

Pulmonary Vascular Resistance

Distribution of Blood Flow

Methods of Evaluating the Pulmonary Circulation

Muscles of Respiration

Gas Exchange

Alveolar Ventilation

Dead Space

Diffusion

Shunt and Ventilation-Perfusion Relationships

Systemic Gas Transport

Oxygen Therapy

Carbon Dioxide Transport and Acid-Base Balance

Tissue Respiration

Regulation of Respiration

Sensory Feedback System

Metabolic Functions of the Lung

References

7 Biology and Assessment of Airway Inflammation

Introduction

Allergic Inflammation

Acute Inflammation

Chronic Inflammation

Inflammatory Cells

Structural Cells as Sources of Mediators

Inflammatory Mediators

Neural Mechanisms

Transcription Factors

Antiinflammatory Mechanisms

Direct Measurements of Airway Inflammation

Noninvasive Assessment of Airway Inflammation

Is AHR an Inflammatory Surrogate?

Other Potential Indirect Inflammatory Markers

Is There a Role for Assessing Inflammation in Pediatric Respiratory Disease?

Therapeutic Implications

Conclusion

References

8 Lung Defenses

Intrinsic Lung Defenses

Innate Lung Defenses

Adaptive Lung Defenses

Role of Programmed Cell Death and “Clearing the Garbage” in Lung Homeostasis

Summary

References

9 Bronchoscopy and Bronchoalveolar Lavage in Pediatric Patients

Instrumentation

Techniques for Bronchoscopy

Anesthesia for Bronchoscopy

Indications for Diagnostic Bronchoscopy

Contraindications to Bronchoscopy

Bronchoalveolar Lavage

Diagnostic Techniques Other Than Bronchoalveolar Lavage

Therapeutic Bronchoscopy

Complications of Bronchoscopy

Economic Aspects of Bronchoscopy

References

10 Diagnostic Imaging of the Respiratory Tract

Plain Radiography

Specific Features of the Chest Radiograph in Children

Systematic Review of the Chest Radiograph

Fluoroscopic Techniques

Computed Tomography

Isotropic Computed Tomography

Data Processing

Review of Findings

Pitfalls

Radiation Dose

High-Resolution Computed Tomography

Controlled Ventilation Technique

Interpretation

Angiography

Magnetic Resonance Imaging

Endobronchial Ultrasonography

Ultrasonography

Radionuclide Imaging

Conclusion

References

11 Pulmonary Function Tests in Infants and Children

Introduction

Measurement of Lung Volumes

Measurement of Diffusing Capacity of Carbon Monoxide

Measurement of Forced Expiration

Measurement of Resistance and Compliance

Measurement of Gas Mixing

References

12 Exercise and Lung Function in Child Health and Disease

The Biological Importance of Physical Activity in the Growing Child

From the Playground to the Bench to the Physician’s Office

Physiologic Response to Progressive Exercise Testing

The Challenge of Scaling Cardiopulmonary Exercise Testing to Body Mass in Children and Adolescents and the Special Case of Obesity

Development of Physiological Responses to Exercise in Children and Adolescents and Predicting Cardiopulmonary Health Across the Lifespan

Searching for Normal Values in Pediatric Cardiopulmonary Exercise Testing

Asthma and Exercise

Physical Activity, Exercise and Cystic Fibrosis

Physical Activity, Exercise, and Lung Disease of Prematurity

Exercise at Altitude in Child Health

High Altitude and Children With Chronic Lung Disease

Exercise and Laryngeal Obstruction

Toward the Future: Exercise in the Age of Omics

References

13 Integrating Patient-Reported Outcomes Into Research and Clinical Practice

Definition of a Patient-Reported Outcome

Development and Utilization of Patient-Reported Outcomes

Health-Related Quality of Life Measures

Developmental Considerations

Use of Proxy-Respondents

Clinical Utility

Summary

Review of Disease-Specific Respiratory Health-Related Quality of Life Measures

Conclusions and Future Directions

References

14 Transition From Pediatric to Adult Care

Introduction

What Is Transition?

Why Is Transition Important?

Transition: A Practical Approach

Barriers to Transition

Summary

References

15 Long-Term Consequences of Childhood Respiratory Disease

Introduction

How the Lung Develops in Health and Disease

The End-Stage—Chronic Obstructive Pulmonary Disease

Long-Term Consequences of Specific Diseases

Summary and Conclusions

References

16 Drug Administration by Inhalation in Children

Advantages and Disadvantages of Aerosols for Drug Delivery

What Is a Therapeutic Aerosol?

Principles of Aerosol Delivery

Assessment Techniques

Aerosol Devices

Dosage Considerations

Advice and Training for Parents

Progress Toward the Ideal Delivery System

References

17 Physical Therapies in Pediatric Respiratory Disease

General Principles of Physiotherapy

Role of Physiotherapy in Pediatric Respiratory Disease

Respiratory Physiotherapy in Specific Conditions

Conditions Not Generally Amenable to Physiotherapy

Summary

References

18 Congenital Lung Disease

Introduction

Clinical Approach

The Size of the Problem: Epidemiology of Congenital Malformations of the Lung

Antenatal Diagnosis and Management of Congenital Lung Disease

Specific Diagnoses: Congenital Diaphragmatic Hernia

Specific Diagnoses: Upper Respiratory Tract Atresias

Specific Postnatal Problems: Congenital Abnormalities of the Upper Airway

Examination of a Child Presenting in the Clinic Setting

The Emergent/Marginal Airway and Difficult Intubations

Extubation Difficulties/Failed Extubation

Congenital Abnormalities of the Larynx

Vocal Cord Paralysis

Congenital Abnormalities of the Trachea

Specific Problems: Congenital Bronchial Abnormalities

Specific Problems: Parenchymal Lesions

Specific Problems: Overexpansion, Aplasia and Ectopia

Specific Problems: Abnormal Connections Between the Bronchial Tree and Other Structures

Specific Problems: Congenital Disease of the Pulmonary Arterial Tree

Specific Problems: Congenital Disease of the Pulmonary Venous Tree

Specific Problems: Abnormalities of the Connections Between the Pulmonary Arterial and Venous Trees

Specific Problems: Congenital Disease of the Lymphatic Tree

Specific Problems: Congenital Disorders of the Chest Wall

Specific Problems: Congenital Cardiac Disorders

Specific Problems: Multisystem Congenital Disorders That Affect the Lung

Role of Specific Investigations

Summary and Conclusions

References

19 Respiratory Disorders in the Newborn

Initiation of Respiration at Birth

Fetal Lung Fluid

Respiratory Depression at Birth

Delivery Room Resuscitation

Ventilatory Control

Respiratory Distress Syndrome

Transient Tachypnea of the Newborn

Meconium Aspiration Syndrome

Acute Respiratory Distress Syndrome

Early-Onset Pneumonia

Late-Onset Pneumonia

Aspiration Pneumonia

Interstitial Lung Disease

Persistent Pulmonary Hypertension of the Newborn

Pulmonary Hypertension in Bronchopulmonary Dysplasia

Pneumothorax

Pneumomediastinum

Pneumopericardium

Pulmonary Interstitial Emphysema

Secondary Pulmonary Hypoplasia

Patent Ductus Arteriosus

Pulmonary Edema

Pulmonary Hemorrhage

Upper Airway Obstruction

Gastroesophageal Reflux

References

20 Bronchopulmonary Dysplasia

Introduction

Definition

Epidemiology

Etiology

Pathogenesis

Pathophysiology

Clinical Findings

Prevention

Treatment

Prognosis

Summary

References

21 Children Dependent on Respiratory Technology

Introduction

Epidemiology

Goals of Therapy

General Considerations for Home Care

Treatment of Chronic Respiratory Failure

Ancillary Equipment

Patient Follow-Up

Outcomes

Summary

References

Section 2 Infections of the Lung

22 Microbiological Diagnosis of Respiratory Illness

Respiratory Pathogens and Syndromes

Use of the Clinical Microbiology Laboratory

Microbiome

Future Prospects

References

23 Acute Infections That Produce Upper Airway Obstruction

Viral Laryngotracheobronchitis

Diagnosis and Differential Diagnosis

Epiglottitis

Bacterial Tracheitis

Diphtheria

Retropharyngeal Abscess

Peritonsillar Abscess (Quinsy)

Infectious Mononucleosis

References

24 Bronchiolitis

Epidemiology

Etiology

Pathology/Pathogenesis

Clinical Features

Diagnosis and Differential Diagnosis

Management and Treatment

Prevention

Prognosis

References

25 Pneumonia in Children

Epidemiology and Etiology

Pathogenesis

Clinical Features

Etiologic Diagnosis

Diagnosis and Differential Diagnosis

General Management

Treatment With Antimicrobials

Slowly Resolving Pneumonia

Major Clinical Complications

Prevention

Prognosis

References

26 Bronchiectasis and Chronic Suppurative Lung Disease

Introduction

Definitions

Bronchiectasis and Chronic Suppurative Lung Disease

Protracted Bacterial Bronchitis

References

27 Influenza

Introduction

Epidemiology

Pathology/Pathogenesis

Clinical Features

Diagnosis and Differential Diagnosis

Management and Treatment

Prevention

Prognosis/Outcome

References

28 New and Emerging Infections of the Lung

Introduction

Middle East Respiratory Syndrome Coronavirus

Human Metapneumovirus

Rhinovirus C

Adenovirus

References

29 Tuberculosis

Epidemiology

Mycobacteriology

Immunology

Pathophysiology

Clinical Features

Diagnosis

Tests of Infection

Laboratory Diagnosis

Treatment

Control and Prevention

References

30 Nontuberculosis Mycobacterial Disease

Microbiology

Epidemiology

Acquisition and Potential for Transmission

Apparent Increase in Nontuberculous Mycobacteria Vulnerable Populations and in the Modern Environment

Clinical Manifestations of Nontuberculous Mycobacteria Pulmonary Disease

Diagnosis of Nontuberculous Mycobacteria Pulmonary Disease

Management and Treatment

Outcomes

References

31 The Pulmonary Mycoses

Introduction

Antifungal Drugs

Endemic Mycoses

Pulmonary Mycoses Primarily Seen in Hosts With Impaired Immunity

References

32 Pertussis and Other Bordetella Infections of the Respiratory Tract

Epidemiology

Etiology

Pathology/Pathogenesis

Clinical Features

Imaging, Pulmonary Function Testing, Laboratory Findings

Diagnosis and Differential Diagnosis

Management and Treatment

Prevention

Prognosis

References

33 Toxocariasis, Hydatid Disease of the Lung, Strongyloidiasis, and Pulmonary Paragonimiasis

Toxocariasis

Echinococcosis (Hydatid Disease)

Strongyloidiasis

Pulmonary Paragonimiasis (Lung Fluke Disease)

References

Section 3 Pulmonary Disease in the Intensive Care Unit

34 Principles of Mechanical Ventilation

History

Indications for Mechanical Ventilation

Composition of a Mechanical Ventilator

Modes of Ventilation

Noninvasive Ventilation

High-Frequency Ventilation

Neurally Adjusted Ventilator Assistance

Hemodynamic Effects of Mechanical Ventilation

Mechanical Ventilation in Specific Conditions

Management During Mechanical Ventilation

Complications of Mechanical Ventilation

Conclusion

References

35 Childhood Pulmonary Arterial Hypertension

Introduction

Definition and Classification

Epidemiology and Etiology

Neonatal Pulmonary Hypertension

Associated Pulmonary Arterial Hypertension With Congenital Heart Disease

Management

Oxygen

Additional Pharmacotherapy: Cardiac Glycosides, Diuretics, Antiarrhythmic Therapy, Inotropic Agents, and Nitrates

Atrial Septostomy

Lung Transplantation

Conclusions

References

36 Pulmonary Edema

Anatomic Considerations

Factors Responsible for Fluid Movement

Mechanisms That Cause Pulmonary Edema

Clearance of Pulmonary Edema Fluid

Pathophysiologic Consequences of Edema

Clinical Presentation

Clinical Disorders Causing Pulmonary Edema

Therapy

References

37 Respiratory Complications of Intensive Care

History of Pediatric Intensive Care

Indications for Intubation and Mechanical Ventilation

Ventilation Strategies

Complications of Mechanical Ventilation

Conclusion

References

38 Acute Respiratory Distress Syndrome

Epidemiology

Etiology

Outcome

Definition and Diagnosis

Pathophysiology

Treatment

Summary/Conclusion

References

39 Pulmonary Disease Associated With Congenital Heart Disease

Introduction

Airway Compression Due to Vascular Rings and Slings

Pulmonary Hypertension and Postoperative Pulmonary Hypertensive Crisis

Pulmonary Vein Stenosis

Reperfusion Pulmonary Edema in Children Undergoing Procedures for Tetralogy of Fallot, Pulmonary Atresia and Multiple Aortopulmonary Collateral Arteries

Pulmonary Disease Associated With the Fontan Repair of Single Ventricle Physiology

Pulmonary Complications Related to Cardiac Surgery and Cardiopulmonary Bypass

Conclusion

References

40 Lung Injury From Hydrocarbon Aspiration and Smoke Inhalation

Epidemiology

Etiology

Pathology

Pathophysiology

Clinical Findings

Diagnosis and Differential Diagnosis

Management and Treatment

Prevention

Prognosis

Hydrocarbon “Sniffing”

Respiratory Complications of Smoke Inhalation

The Relationship of Pulmonary Injury From Smoke Inhalation to the Pulmonary Complications of Surface Burns

References

41 Drowning

Definitions

Epidemiology

Drowning Sequence

Sequelae of Submersion/Immersion Events

References

Section 4 Asthma

42 The Epidemiology of Asthma

Overview

Epidemiologic Approaches to the Study of Asthma

Defining Asthma in Epidemiologic Studies

The Prevalence of Asthma

Severity and Mortality

Quality of Life and Economic Impact of Asthma

Phenotypic Variation

The Genetics of Asthma

Environmental Influences on Asthma

Conclusions

References

43 The Immunopathogenesis of Asthma

Altered Pulmonary Immunity in Asthma Inception

Cells, Molecules, and Cytokines Involved in Pediatric Allergic Asthma

School-Age Allergic Asthma: Pathology and Mechanisms

The Clinical Relevance of Eosinophilic Inflammation in School-Age Asthma

Essential Role of Structural Airway Cells in Pulmonary Immunity and Asthma Pathogenesis

Preschool Wheeze: A Unique Maturing Immune Environment

Specific Clinical Scenarios for Consideration

Summary

References

44 Asthma in the Preschool Age Child

Epidemiology and Burden

Diagnosis

Natural History

Pathology

Treatment

References

45 Wheezing in Older Children

Introduction

Pathology

Pathophysiology

Inflammatory Cell Biology and Asthma Etiology and Pathophysiology

Natural History and Prognosis

Asthma Mortality

Diagnosis of Asthma

Nonallergic Hypersensitivity to Drugs and Chemicals

Laboratory Diagnosis

Lung Function Tests

Bronchial Challenge Tests

Exercise Challenge Test

Other Tests

Therapeutic Considerations

Classification of Asthma

Pharmacologic Management of Asthma in Children Older Than 5 Years of Age

Reliever Medications: Short-Acting β Agonists

Anticholinergic Agents

Controller Medications

Other Inhaled Corticosteroids

Systemic Corticosteroids

Leukotriene Antagonists

Long-Acting Muscarinic Antagonists

Management of Chronic Asthma

Intermittent Asthma

Mild Persistent Asthma

Moderate Persistent Asthma

Severe Persistent Asthma

Holding Chambers and Spacer Devices

Peak Expiratory Flow Rate Monitoring

Nonpharmacologic Measures

Management of an Acute Episode

Hospital Management of Asthma

General Treatment

References

46 Severe Asthma

Overarching Principles

Definitions

A New Approach: Airways Disease Deconstructed and Placed in Context

Initial Evaluation: Problematic Severe Asthma

Problematic Severe Asthma: Not Asthma at All

Airway Disease in Context: Asthma Plus (Extrapulmonary Comorbidities)

Airway Disease in Context: Environmental/Lifestyle (Difficult Asthma)

Increasingly Important in the Assessment Process: A Hospital Admission

Difficult Asthma: Summary

Severe, Therapy-Resistant Asthma: Deconstructing the Airway Disease

Assessment of Persistent Airflow Limitation

Treatment of Severe, Therapy-Resistant Asthma

Monitoring the Child With Severe, Therapy-Resistant Asthma on Treatment

Summary and Conclusions

References

47 The Influence of Upper Airway Disease on the Lower Airway

Allergic Rhinitis and Asthma

Chronic Rhinosinusitis and Asthma

References

48 Modern Molecular Therapies for Application in Managing Childhood Asthma

Introduction

Allergen Immunotherapy

Omalizumab

Mepolizumab

Other Biologics

Conclusion

References

Section 5 Cystic Fibrosis

49 Genetics and Pathophysiology of Cystic Fibrosis

CFTR Gene

CFTR Protein

Genotype-Phenotype Correlations

Pathophysiology

Cystic Fibrosis Animal Models

Characteristics of Systemic Disease

Other Disorders Related to the Cystic Fibrosis Transmembrane Conductance Regulator

References

50 Diagnosis and Presentation of Cystic Fibrosis

Diagnostic Criteria for Cystic Fibrosis

Making the Diagnosis of Cystic Fibrosis

Antenatal Testing for Cystic Fibrosis

Neonatal Screening for Cystic Fibrosis

The Phenotypic Spectrum of Cystic Fibrosis—Influencing Factors

Cystic Fibrosis Phenotypes

References

51 Pulmonary Disease in Cystic Fibrosis

Epidemiology

Etiology and Pathogenesis

Clinical Features

Management and Treatment

Prognosis

Conclusions

References

52 Nonpulmonary Manifestations of Cystic Fibrosis

Pancreatic Disease

Fibrosing Colonopathy

Pancreatitis

Hepatobiliary Disease

Gallbladder Disease

Infertility

Cystic Fibrosis Transmembrane Conductance Regulator Actions in the Small Bowel

Constipation

Distal Intestinal Obstruction Syndrome

Rectal Prolapse

Gastric Emptying and Small Bowel Motility

Small Intestine Bacterial Overgrowth

GI Cancers

Nutrition

Cystic Fibrosis–Related Diabetes

Conclusion

References

53 Molecular Therapies for Cystic Fibrosis

Introduction

Small Molecule Cystic Fibrosis Transmembrane Conductance Regulator Modulators

Read-Through Agents

Potentiators

Correctors

Combination Therapy

Other Noncystic Fibrosis Transmembrane Conductance Regulator–Based Approaches

Cystic Fibrosis Gene Therapy

Evaluating Therapies Targeting the Basic Defect in Clinical Trials

Challenges for the Field

Summary

Declaration of Interests

References

Section 6 Interstitial Lung Disease

54 New Concepts in Children’s Interstitial and Diffuse Lung Disease

New Concepts, Terminology, and Classification

General Diagnostic Approach

Resources for Families and Physicians

References

55 Rare Childhood Lung Disorders

Introduction

Respiratory Disorders of the Lymphatic System

Lymphangioleiomyomatosis

Pulmonary Alveolar Microlithiasis

Ataxia Telangiectasia

Gaucher Disease

Niemann-Pick Disease

Neurofibromatosis

Dyskeratosis Congenita

Hermansky-Pudlak Syndrome

Alpha-1 Antitrypsin Deficiency

Summary

References

56 Childhood Interstitial Lung Disease Disorders More Prevalent in Infancy

Overview

Alveolar Capillary Dysplasia With Misalignment of Pulmonary Veins

Radiologic Findings

Lung Growth Abnormalities Presenting as Childhood Interstitial Lung Diseases

Radiologic Findings

Pulmonary Interstitial Glycogenosis

Neuroendocrine Cell Hyperplasia of Infancy

Summary

References

57 Lung Diseases Associated With Disruption of Pulmonary Surfactant Homeostasis

Epidemiology

Etiology

Pathology/Pathogenesis

Clinical Features of Surfactant Production Disorders

Diagnosis and Differential Diagnosis

Management, Treatment, and Prognosis

Summary

References

58 Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood

Overview of Chapter

Juvenile Idiopathic Arthritis

Systemic Lupus Erythematosus

Juvenile Dermatomyositis

Scleroderma

Mixed Connective Tissue Disease

Sarcoidosis

Childhood Vasculitides

Granulomatosis With Polyangiitis

Other Systemic Inflammatory Diseases With Significant Pulmonary Involvement

Clinical Approach to Diagnosis and Management of Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood

References

59 Lung Injury Caused by Pharmacologic Agents

Cytotoxic Drugs Used in Cancer Therapy

Noncytotoxic and Other Drugs

Other Agents

Conclusion

References

Section 7 Miscellaneous Disorders of the Lung

60 Pulmonary Embolism and Thromboembolic Disease

Epidemiology

Etiology

Pathology/Pathogenesis

Clinical Features

Diagnosis and Differential Diagnosis

Imaging

Additional Diagnostic Testing

Management

Prevention

References

61 Diffuse Alveolar Hemorrhage in Children

Etiology of Diffuse Alveolar Hemorrhage

Approach to the Child With Pulmonary Hemorrhage

Summary

References

62 The Lung in Sickle Cell Disease

Epidemiology

Etiology

Pathogenesis

Clinical Features

Diagnosis

Management

Prevention

Prognosis

References

63 Primary Immunodeficiency and Other Diseases With Immune Dysregulation

Chronic Granulomatous Disease

Common Variable Immunodeficiency Disorders

Other Immunodeficiencies With Pulmonary Manifestations

References

64 Pulmonary Disease in the Pediatric Patient With Acquired Immunodeficiency States

Introduction

Pulmonary Infections in the Immunocompromised Pediatric Host

Clinical Presentation of Pulmonary Infection in the Immunocompromised Child

Infectious Risks Shared by Malignancy, Solid Organ Transplantation, and Stem Cell Transplantation

Common Pulmonary Infectious Agents in the Immunocompromised Pediatric Host

Pulmonary Complications Following Solid-Organ Transplantation

Pulmonary Complications of Childhood Tumors and Their Treatment

Pulmonary Complications of Hematopoietic Stem Cell Transplantation

Approach to Pulmonary Disease in the Immunocompromised Pediatric Host

Noninvasive Diagnostic Studies

Invasive Diagnostic Studies

Prevention Strategies

References

65 Hypersensitivity Pneumonitis and Eosinophilic Lung Diseases

Hypersensitivity Pneumonitis

Eosinophilic Pulmonary Diseases

Allergic Bronchopulmonary Aspergillosis

Drug-Induced Eosinophilia

Acute Eosinophilic Pneumonia

Chronic Eosinophilic Pneumonia

Eosinophilic Granuloma (Pulmonary Langerhans Cell Histiocytosis)

Helminth Associated Eosinophilic Lung Disease

Churg-Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis)

Hypereosinophilic Syndrome

References

66 Respiratory Disorders in Human Immunodeficiency Virus–Infected Children and Adolescents

Spectrum of Respiratory Disease

Acute Respiratory Disease

Chronic Lung Disease

Lung Function as a Measurement of Chronic Lung Disease

Human Immunodeficiency Virus-Associated Cardiomyopathy and Pulmonary Hypertension

Upper Airway Disease

Summary

References

67 Pediatric Lung Transplantation

Introduction

Indications and Timing

Contraindications

Surgical Technique

Posttransplant Management

Management Issues Unique to Pediatrics

Complications

Outcomes

Future Directions

References

68 Respiratory Complications of Down Syndrome

Introduction

Upper Airway Disease and the Trachea

Sleep-Related Breathing Disorders

Lower Respiratory Tract

Imaging of the Lower Respiratory Tract in Down Syndrome

Cardiorespiratory Interactions and Pulmonary Vasculature

Gastrointestinal–Respiratory Interactions in Down Syndrome

Obesity and Its Impact on the Lung in Down Syndrome

Conclusions

Other Genetic Anomalies

References

69 Air and Fluid in the Pleural Space

Embryology and Anatomy

Physiology

Air in the Pleural Space: Pneumothorax

Flying and Diving After Pneumothorax

Fluid in the Plural Space

Conclusion

References

70 Atelectasis

Etiology and Pathogenesis

Pathogenic Mechanisms

Clinical Manifestations

Diagnosis

Treatment and Management

Prevention of Atelectasis

References

71 Primary Ciliary Dyskinesia

Epidemiology

Etiology

Pathology and Pathogenesis

Clinical Features

Diagnosis

Management and Treatment

Prognosis

References

72 Chest Wall and Respiratory Muscle Disorders

Introduction

Etiologies

Pathogenesis

Clinical Features

Diagnosis

Management

References

73 Disorders of the Respiratory Tract Caused by Trauma

General Considerations

Features of the Pediatric Thorax

Sternal Fractures

Rib Fractures and Flail Chest

Traumatic Pneumothorax

Hemothorax

Tracheobronchial Trauma

Pulmonary Compression Injury (Traumatic Asphyxia)

Posttraumatic Atelectasis

Cardiac Trauma

Traumatic Rupture of the Thoracic Aorta

Injuries to the Esophagus

Traumatic Blunt Rupture of the Diaphragm

Thoracoabdominal Injuries

References

74 Tumors of the Chest

Epidemiology

Etiology

Benign Primary Pulmonary Lesions

Malignant Primary Pulmonary Lesions

Chest Wall Tumors

Mediastinal Tumors

Primary Cardiac and Pericardial Tumors

Tumors of the Diaphragm

General Approach to Evaluation of Children With Suspected Tumors of the Chest

Management and Treatment of Thoracic Tumors

References

Section 8 The Aerodigestive Model

75 The Aerodigestive Model

Historical Perspective

Patient Selection

Screening and Evaluating Potential Patients

The Interdisciplinary Team

Value in Coordinated Aerodigestive Care

Summary

References

76 Aspiration

Introduction

Aspiration Caused by Swallowing Dysfunction

Evaluation of Swallowing

Aspiration of Gastroesophageal Reflux

Aspiration of Oral Secretions

Evaluation of Lung Injury Caused by Aspiration

Multidisciplinary Approach to Chronic Aspiration

References

77 Feeding and Swallowing Disorders

Introduction

Epidemiology

Anatomy, Physiology, and Development

Etiology/Pathogenesis

Conditions Associated With Feeding, Swallowing, and Airway Protection Problems

Imaging, Instrumental Assessment of Swallowing Function, and Airway Protection

Diagnosis, Management, and Treatment

Evaluation and Management

Treatment Strategies

Summary

References

78 Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease

Gastroesophageal Reflux Disease

Disorders of Motility

Eosinophilic Esophagitis

References

79 Laryngeal and Tracheal Airway Disorders

Introduction

Operative Assessment

Mitigating Factors

Optimization

Management of Airway Pathology

References

80 Sudden Infant Death Syndrome and Apparent Life-Threatening Events

Acute Life-Threatening Events (ALTE) and BRUE

Etiology and Pathology/Pathogenesis

Apnea in Premature Infants

Monitoring Premature Infants at Home

Sudden Infant Death Syndrome

Summary

Acknowledgments

References

81 Disorders of Breathing During Sleep

Basic Mechanisms and Architecture of Normal Sleep

Developmental Aspects of Sleep

Respiratory Control Mechanisms

The Upper Airway

Upper Airway Dysfunction

Apnea

References

Index

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Robert Wilmott,Andrew Bush,Robin Deterding,Felix Ratjen,Peter Sly,Heather Zar,Albert Li,Kendig Disorders,Respiratory