Lysosomes Biology Diseases and Therapeutics 1st Edition by Frederick R Maxfield,James M Willard,Shuyan Lu ISBN 1118645154 978-1118645154

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Product details:

ISBN 10: 1118645154 

ISBN 13: 978-1118645154

Author: Frederick R. Maxfield, James M. Willard, Shuyan Lu

 Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.

•    Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates
•    Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair
•    Introduces new pathways in therapeutic development and new mechanisms in drug development

Table of contents:

 Chapter 1 Lysosomes: An Introduction
Chapter 2 Lysosome Biogenesis and Autophagy
Chapter 3 Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling
Chapter 4 Lysosomes and Mitophagy
Chapter 5 Lysosome Exocytosis and Membrane Repair
Chapter 6 Role of Lysosomes in Lipid Metabolism
Chapter 7 TFEB, Master Regulator of Cellular Clearance
Chapter 8 Lysosomal Membrane Permeabilization in Cell Death
Chapter 9 The Lysosome in Aging-Related Neurodegenerative Diseases
Chapter 10 Lysosome and Cancer
Chapter 11 The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases
Chapter 12 Lysosome-Related Organelles: Modifications of the Lysosome Paradigm
Chapter 13 Autophagy Inhibition as a Strategy for Cancer Therapy
Chapter 14 Autophagy Enhancers, Are We There Yet?
Chapter 15 Pharmacological Chaperones as Potential Therapeutics for Lysosomal Storage Disorders
Chapter 16 Endosomal Escape Pathways for Delivery of Biologics
Chapter 17 Lysosomes and Antibody–Drug Conjugates
Chapter 18 The Mechanisms and Therapeutic Consequences of Amine-Containing Drug Sequestration in Lysosomes
Chapter 19 Lysosome Dysfunction: An Emerging Mechanism of Xenobiotic-Induced Toxicity
Chapter 20 Lysosomes and Phospholipidosis in Drug Development and Regulation

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Tags: Frederick R Maxfield, James M Willard, Shuyan Lu, Lysosomes Biology, Diseases and Therapeutics