Mathematical Modeling of Biosensors 2nd Edition by Romas Baronas, Feliksas Ivanauskas, Juozas Kulys ISBN 9783030655044 3030655040

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Product details:

ISBN 10:  3030655040

ISBN 13: 9783030655044

Author: Romas Baronas, Feliksas Ivanauskas, Juozas Kulys 

This newly designed and enlarged edition offers an up-to-date presentation of biosensor development and modeling from both a chemical and a mathematical point of view. An entire new chapter in particular is dedicated to optimal design of biosensors. Two more new chapters discuss biosensors which utilize microbial cells and are based on carbon nanotubes respectively. All the other chapters have been revised and updated.

The book contains unique modeling methods for amperometric, potentiometric and optical biosensors based mainly on biocatalysts . It examines processes that occur in the sensors’ layers and at their interface, and it provides analytical and numerical methods to solve equations of conjugated enzymatic (chemical) and diffusion processes. The action of single enzyme as well as polyenzyme biosensors and biosensors based on chemically modified electrodes is studied. The modeling of biosensors that contain perforated membranes and multipart mass transport profiles is critically investigated. Furthermore, it is fully described how signals can be biochemically amplified, how cascades of enzymatic substrate conversion are triggered, and how signals are processed via a chemometric approach and artificial neuronal networks. The results of digital modeling are compared with both proximal analytical solutions and experimental data.

Table of contents: 

1. Biosensor Action

2. Modeling Biosensors at Steady State and Internal Diffusion Limitations

3. Modeling Biosensors at Steady State and External Diffusion Limitations

4. Modeling Biosensors Utilizing Microbial Cells

5. Modeling Nonstationary State of Biosensors

6. Mono-Layer Mono-Enzyme Models of Biosensors

7. One-Layer Multi-Enzyme Models of Biosensors

8. Multi-Layer Models of Biosensors

9. Modeling Biosensors of Complex Geometry

10. The Difference Schemes for the Diffusion Equation

11. The Difference Schemes for the Reaction–Diffusion Equations

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Tags: Romas Baronas, Feliksas Ivanauskas, Juozas Kulys, Mathematical Modeling, Biosensors