Medicinal Chemistry Approaches to Personalized Medicine 1st Edition Karen Lackey

Medicinal Chemistry Approaches to Personalized Medicine 1st Edition Karen Lackey – Ebook Instant Download/Delivery ISBN(s): 9783527333943,9783527677252,3527333940,3527677259

Product details:

• ISBN 13: 9783527333943
• Author: Karen

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.

Numerous case studies from the first generation of “personalized drugs” are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.

Table of contents:

MEDICINAL CHEMISTRY APPROACHES TO CREATING TARGETED MEDICINES

DISCOVERY OF PREDICTIVE BIOMARKERS FOR ANTICANCER DRUGS

CRIZOTINIB

DISCOVERY AND DEVELOPMENT OF VEMURAFENIB: FIRST-IN-CLASS INHIBITOR OF MUTANT BRAF FOR THE TREATMENT OF CANCER

TARGETING BASAL-CELL CARCINOMA: DISCOVERY AND DEVELOPMENT OF VISMODEGIB (GDC-0449), A FIRST-IN-CLASS INHIBITOR OF THE HEDGEHOG PATHWAY

G-QUADRUPLEXES AS THERAPEUTIC TARGETS IN CANCER

IDENTIFYING ACTIONABLE TARGETS IN CANCER PATIENS

DNA DAMAGE REPAIR PATHWAYS AND SYNTHETIC LETHALITYAMYLOID CHEMICAL PROBES AND THERANOSTICS: STEPS TOWARD PERSONALIZED MEDICINE IN NEURODEGENERATIVE DISEASES

FROM HUMAN GENETICS TO DRUG CANDIDATES: AN INDUSTRIAL PERSPECTIVE ON LRRK2 INHIBITION AS A TREATMENT FOR PARKINSON’S DISEASE

THERAPEUTIC POTENTIAL OF KINASES IN ASTHMA

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