Modeling Neuropsychiatric Disorders in Laboratory Animals 1st Edition by Kurt Leroy Hoffman 0081000991 9780081000991

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Product details:

ISBN-10 :  0081000991 

ISBN-13 :  9780081000991

Author:  Kurt Leroy Hoffman 

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders.

The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease.

Modeling Neuropsychiatric Disorders in Laboratory Animals 1st Table of contents:

1: What is an animal model of a neuropsychiatric disorder?
Abstract
1.1 Introduction
1.2 What is a neuropsychiatric disorder? (and what is not?)
1.3 What is an animal model of a neuropsychiatric disorder?
1.4 General types of animal models
1.5 Animal model or model animal?
1.6 Validating an animal model
1.7 Endophenotypes and biologic markers
1.8 Chapter overview and perspectives
2: What can animal models tell us about depressive disorders?
Abstract
2.1 Depressive disorders
2.2 Neurobiology of depressive disorders
2.3 Relationship to normalcy
2.4 Endophenotypes of depressive disorders
2.5 Gene variants associated with depression
2.6 Measuring endophenotypes in rodent models
2.7 Animal models
2.8 Model animals
2.9 Chapter overview and perspectives
3: Modeling disorders of fear and anxiety in animals
Abstract
3.1 Anxiety disorders
3.2 Neurobiology of anxiety disorders
3.3 Relationship to normalcy
3.4 Endophenotypes of anxiety disorders
3.5 Genes and anxiety
3.6 Measuring endophenotypes in rodent models
3.7 Animal models
3.8 Model animals
3.9 Chapter overview and perspectives
4: Animal models for studying obsessive-compulsive and related disorders
Abstract
4.1 Obsessive–compulsive and related disorders
4.2 OCD within the internalizing dimension of disorders
4.3 OCD as a multidimensional disorder
4.4 The OCD spectrum of disorders
4.5 Neurobiology of OCD
4.6 Relationship to normalcy
4.7 Endophenotypes of OCD and related disorders
4.8 Genetics of OCD
4.9 Endophenotype tests in rodents
4.10 Animal models
4.11 Model animals
4.12 Chapter overview and perspectives
5: New dimensions in animal modeling of neuropsychiatric disorders
Abstract
5.1 Comorbidity of mental illness
5.2 Endophenotypes of depression, anxiety disorders, and obsessive–compulsive disorder
5.3 New “dimensions” in animal modeling of neuropsychiatric disorders
5.4 A closer look at the world of rats and mice
5.5 How far can we take cross-species comparisons?
5.6 The importance of the individual
5.7 Some environmental factors that influence the development of stable individual differences
5.8 Chapter overview and perspectives

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Tags: Modeling Neuropsychiatric, Disorders, Laboratory Animals, Kurt Leroy Hoffman